Development and characterization of self-etching adhesives doped with 45S5 and niobophosphate bioactive glasses: Physicochemical, mechanical, bioactivity and interface properties.: Physicochemical, mechanical, bioactivity and interface properties

Edilausson Moreno Carvalho; Paulo Vitor Campos Ferreira; Mario Felipe Gutiérrez; Ruan Ferreira Sampaio; Ceci Nunes Carvalho; Alan Silva de Menezes; Alessandro Dourado Loguercio; José Bauer

doi:10.1016/j.dental.2021.03.004

Development and characterization of self-etching adhesives doped with 45S5 and niobophosphate bioactive glasses: Physicochemical, mechanical, bioactivity and interface properties. Physicochemical, mechanical, bioactivity and interface properties

Edilausson Moreno Carvalho, Paulo Vitor Campos Ferreira, Mario Felipe Gutiérrez, Ruan Ferreira Sampaio, Ceci Nunes Carvalho, Alan Silva de Menezes, Alessandro Dourado Loguercio, José Bauer^*

^*Corresponding author for this work

Facultad de Odontología

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Objective: The aim of study was to develop and characterize experimental bioactive glasses (45S5 and niobophosphate bioactive glass (NbG)) and evaluate the effects of their addition in self-etching adhesive systems on physicochemical, mechanical, and bioactive properties, microtensile bond strength (μTBS), and nanoleakage (NL).

Methods: Two-step self-etching adhesive systems containing 5, 10, and 20 wt.% of 45S5 and NbG bioactive glasses were developed. An experimental adhesive without microparticles and a commercial adhesive (Clearfil SE Bond) were used as control groups. The materials were evaluated for their degree of conversion (DC%), ultimate tensile strength (UTS), softening in solvent, radiopacity, sorption and solubility, alkalizing activity (pH), ionic release, and bioactivity. μTBS and NL were evaluated after 24 h and 1 year of storage. The data were subjected to analysis of variance and post-Holm-Sidak tests (α = 0.05).

Results: The addition of the two bioactive glasses did not change the values of the degree of conversion, ultimate tensile strength, and softening in solvent. The adhesive system containing 20% NbG showed the highest radiopacity. The incorporation of 45S5 increased water sorption and solubility, raised the pH, and allowed the release of large amounts of calcium. After 28 days of immersion in simulated body fluid, the 45S5 adhesive precipitated hydroxyapatite and calcium carbonate (SEM/EDX, ATR/FTIR, and XDR). The addition of 45S5 and NbG to the adhesives improved the stability of the resin-dentin interface after 1 year.

Significance: The incorporation of microparticles from 45S5 bioactive glass in self-etching adhesive systems is considered an excellent alternative for the development of a bioactive adhesive that improves the integrity of the hybrid layer on sound dentin.

Original language	English
Pages (from-to)	1030-1045
Number of pages	16
Journal	Dental Materials
Volume	37
Issue number	6
DOIs	https://doi.org/10.1016/j.dental.2021.03.004 https://doi.org/10.1016/j.dental.2021.03.004
State	Published - 1 Jun 2021

Bibliographical note

Keywords

Alkalizing activity
Bioactive glass
Bioactivity
Ions release
Mechanical properties
Microtensile bonding strength
Nanoleakage
Self-etching adhesive systems
Dentin
Tensile Strength
Materials Testing
Dental Cements
Dental Bonding

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Carvalho, E. M., Ferreira, P. V. C., Gutiérrez, M. F., Sampaio, R. F., Carvalho, C. N., Menezes, A. S. D., Loguercio, A. D., & Bauer, J. (2021). Development and characterization of self-etching adhesives doped with 45S5 and niobophosphate bioactive glasses: Physicochemical, mechanical, bioactivity and interface properties. Physicochemical, mechanical, bioactivity and interface properties. Dental Materials, 37(6), 1030-1045. https://doi.org/10.1016/j.dental.2021.03.004, https://doi.org/10.1016/j.dental.2021.03.004

Carvalho, Edilausson Moreno ; Ferreira, Paulo Vitor Campos ; Gutiérrez, Mario Felipe et al. / Development and characterization of self-etching adhesives doped with 45S5 and niobophosphate bioactive glasses: Physicochemical, mechanical, bioactivity and interface properties. Physicochemical, mechanical, bioactivity and interface properties. In: Dental Materials. 2021 ; Vol. 37, No. 6. pp. 1030-1045.

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title = "Development and characterization of self-etching adhesives doped with 45S5 and niobophosphate bioactive glasses: Physicochemical, mechanical, bioactivity and interface properties.: Physicochemical, mechanical, bioactivity and interface properties",

abstract = "Objective: The aim of study was to develop and characterize experimental bioactive glasses (45S5 and niobophosphate bioactive glass (NbG)) and evaluate the effects of their addition in self-etching adhesive systems on physicochemical, mechanical, and bioactive properties, microtensile bond strength (μTBS), and nanoleakage (NL).Methods: Two-step self-etching adhesive systems containing 5, 10, and 20 wt.% of 45S5 and NbG bioactive glasses were developed. An experimental adhesive without microparticles and a commercial adhesive (Clearfil SE Bond) were used as control groups. The materials were evaluated for their degree of conversion (DC%), ultimate tensile strength (UTS), softening in solvent, radiopacity, sorption and solubility, alkalizing activity (pH), ionic release, and bioactivity. μTBS and NL were evaluated after 24 h and 1 year of storage. The data were subjected to analysis of variance and post-Holm-Sidak tests (α = 0.05).Results: The addition of the two bioactive glasses did not change the values of the degree of conversion, ultimate tensile strength, and softening in solvent. The adhesive system containing 20% NbG showed the highest radiopacity. The incorporation of 45S5 increased water sorption and solubility, raised the pH, and allowed the release of large amounts of calcium. After 28 days of immersion in simulated body fluid, the 45S5 adhesive precipitated hydroxyapatite and calcium carbonate (SEM/EDX, ATR/FTIR, and XDR). The addition of 45S5 and NbG to the adhesives improved the stability of the resin-dentin interface after 1 year.Significance: The incorporation of microparticles from 45S5 bioactive glass in self-etching adhesive systems is considered an excellent alternative for the development of a bioactive adhesive that improves the integrity of the hybrid layer on sound dentin.",

keywords = "Alkalizing activity, Bioactive glass, Bioactivity, Ions release, Mechanical properties, Microtensile bonding strength, Nanoleakage, Self-etching adhesive systems, Dentin, Tensile Strength, Materials Testing, Dental Cements, Dental Bonding",

author = "Carvalho, {Edilausson Moreno} and Ferreira, {Paulo Vitor Campos} and Guti{\'e}rrez, {Mario Felipe} and Sampaio, {Ruan Ferreira} and Carvalho, {Ceci Nunes} and Menezes, {Alan Silva de} and Loguercio, {Alessandro Dourado} and Jos{\'e} Bauer",

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doi = "10.1016/j.dental.2021.03.004",

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Carvalho, EM, Ferreira, PVC, Gutiérrez, MF, Sampaio, RF, Carvalho, CN, Menezes, ASD, Loguercio, AD & Bauer, J 2021, 'Development and characterization of self-etching adhesives doped with 45S5 and niobophosphate bioactive glasses: Physicochemical, mechanical, bioactivity and interface properties. Physicochemical, mechanical, bioactivity and interface properties', Dental Materials, vol. 37, no. 6, pp. 1030-1045. https://doi.org/10.1016/j.dental.2021.03.004, https://doi.org/10.1016/j.dental.2021.03.004

Development and characterization of self-etching adhesives doped with 45S5 and niobophosphate bioactive glasses: Physicochemical, mechanical, bioactivity and interface properties. Physicochemical, mechanical, bioactivity and interface properties. / Carvalho, Edilausson Moreno; Ferreira, Paulo Vitor Campos; Gutiérrez, Mario Felipe et al.
In: Dental Materials, Vol. 37, No. 6, 01.06.2021, p. 1030-1045.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Development and characterization of self-etching adhesives doped with 45S5 and niobophosphate bioactive glasses: Physicochemical, mechanical, bioactivity and interface properties.

T2 - Physicochemical, mechanical, bioactivity and interface properties

AU - Carvalho, Edilausson Moreno

AU - Ferreira, Paulo Vitor Campos

AU - Gutiérrez, Mario Felipe

AU - Sampaio, Ruan Ferreira

AU - Carvalho, Ceci Nunes

AU - Menezes, Alan Silva de

AU - Loguercio, Alessandro Dourado

AU - Bauer, José

PY - 2021/6/1

Y1 - 2021/6/1

N2 - Objective: The aim of study was to develop and characterize experimental bioactive glasses (45S5 and niobophosphate bioactive glass (NbG)) and evaluate the effects of their addition in self-etching adhesive systems on physicochemical, mechanical, and bioactive properties, microtensile bond strength (μTBS), and nanoleakage (NL).Methods: Two-step self-etching adhesive systems containing 5, 10, and 20 wt.% of 45S5 and NbG bioactive glasses were developed. An experimental adhesive without microparticles and a commercial adhesive (Clearfil SE Bond) were used as control groups. The materials were evaluated for their degree of conversion (DC%), ultimate tensile strength (UTS), softening in solvent, radiopacity, sorption and solubility, alkalizing activity (pH), ionic release, and bioactivity. μTBS and NL were evaluated after 24 h and 1 year of storage. The data were subjected to analysis of variance and post-Holm-Sidak tests (α = 0.05).Results: The addition of the two bioactive glasses did not change the values of the degree of conversion, ultimate tensile strength, and softening in solvent. The adhesive system containing 20% NbG showed the highest radiopacity. The incorporation of 45S5 increased water sorption and solubility, raised the pH, and allowed the release of large amounts of calcium. After 28 days of immersion in simulated body fluid, the 45S5 adhesive precipitated hydroxyapatite and calcium carbonate (SEM/EDX, ATR/FTIR, and XDR). The addition of 45S5 and NbG to the adhesives improved the stability of the resin-dentin interface after 1 year.Significance: The incorporation of microparticles from 45S5 bioactive glass in self-etching adhesive systems is considered an excellent alternative for the development of a bioactive adhesive that improves the integrity of the hybrid layer on sound dentin.

AB - Objective: The aim of study was to develop and characterize experimental bioactive glasses (45S5 and niobophosphate bioactive glass (NbG)) and evaluate the effects of their addition in self-etching adhesive systems on physicochemical, mechanical, and bioactive properties, microtensile bond strength (μTBS), and nanoleakage (NL).Methods: Two-step self-etching adhesive systems containing 5, 10, and 20 wt.% of 45S5 and NbG bioactive glasses were developed. An experimental adhesive without microparticles and a commercial adhesive (Clearfil SE Bond) were used as control groups. The materials were evaluated for their degree of conversion (DC%), ultimate tensile strength (UTS), softening in solvent, radiopacity, sorption and solubility, alkalizing activity (pH), ionic release, and bioactivity. μTBS and NL were evaluated after 24 h and 1 year of storage. The data were subjected to analysis of variance and post-Holm-Sidak tests (α = 0.05).Results: The addition of the two bioactive glasses did not change the values of the degree of conversion, ultimate tensile strength, and softening in solvent. The adhesive system containing 20% NbG showed the highest radiopacity. The incorporation of 45S5 increased water sorption and solubility, raised the pH, and allowed the release of large amounts of calcium. After 28 days of immersion in simulated body fluid, the 45S5 adhesive precipitated hydroxyapatite and calcium carbonate (SEM/EDX, ATR/FTIR, and XDR). The addition of 45S5 and NbG to the adhesives improved the stability of the resin-dentin interface after 1 year.Significance: The incorporation of microparticles from 45S5 bioactive glass in self-etching adhesive systems is considered an excellent alternative for the development of a bioactive adhesive that improves the integrity of the hybrid layer on sound dentin.

KW - Alkalizing activity

KW - Bioactive glass

KW - Bioactivity

KW - Ions release

KW - Mechanical properties

KW - Microtensile bonding strength

KW - Nanoleakage

KW - Self-etching adhesive systems

KW - Dentin

KW - Tensile Strength

KW - Materials Testing

KW - Dental Cements

KW - Dental Bonding

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U2 - 10.1016/j.dental.2021.03.004

DO - 10.1016/j.dental.2021.03.004

M3 - Article

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AN - SCOPUS:85103975109

SN - 0109-5641

VL - 37

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JO - Dental Materials

JF - Dental Materials

IS - 6

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Carvalho EM, Ferreira PVC, Gutiérrez MF, Sampaio RF, Carvalho CN, Menezes ASD et al. Development and characterization of self-etching adhesives doped with 45S5 and niobophosphate bioactive glasses: Physicochemical, mechanical, bioactivity and interface properties. Physicochemical, mechanical, bioactivity and interface properties. Dental Materials. 2021 Jun 1;37(6):1030-1045. doi: 10.1016/j.dental.2021.03.004, 10.1016/j.dental.2021.03.004