Detection of CD63+ micro-vesicles, placental alkaline phosphatase and angiogenic markers in gingival crevicular fluid in preeclamptic patients

Alejandra Chaparro, Edgardo Zúñiga, Dominique Gaedechens, Valeria Ramírez, c silva, P. Juan Kusanovic, Karla Silva, Gregory E. Rice, Sebastián Illanes

Research output: Contribution to journalArticlepeer-review

Abstract

Preeclampsia (PE) is a maternal disease that clinically manifests in the second half of pregnancy, characterized by hypertension accompanied by proteinuria and generalized edema. Its complications have become one of the main causes of maternal and fetal morbidity and mortality in the world, causing nearly 40% of premature births delivered before 35 weeks of gestation PE is present in around 5–10% of all pregnant women worldwide and despite the amount of resources invested in the research and treatment of this pathology, it’s still barely predictable and thus difficult to manage clinically. The aim of this study was to determine utility of Cd63+ micro-vesicles, placental alkaline phosphatase and angiogenic biomarkers concentrations in gingival crevicular fluid (GCF) as biomarkers of preeclampsia.
Original languageEnglish
Pages (from-to)A53
Number of pages1
JournalPlacenta
Volume9
Issue number36
DOIs
StatePublished - Sep 2015

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