Delivery of recombinant bone morphogenetic proteins for bone regeneration and repair. Part A: Current challenges in BMP delivery

Ziyad S. Haidar; Reggie C. Hamdy; Maryam Tabrizian

doi:10.1007/s10529-009-0099-x

Delivery of recombinant bone morphogenetic proteins for bone regeneration and repair. Part A: Current challenges in BMP delivery

Ziyad S. Haidar, Reggie C. Hamdy, Maryam Tabrizian^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

207 Scopus citations

Abstract

Recombinant human bone morphogenetic proteins (rhBMPs) have been extensively investigated for developing therapeutic strategies aimed at the restoration and treatment of orthopaedic as well as craniofacial conditions. In this first part of the review, we discuss the rationale for the necessary use of carrier systems to deliver rhBMP-2 and rhBMP-7 to sites of bone tissue regeneration and repair. General requirements for growth factor delivery systems emphasizing the distinction between localized and release-controlled delivery strategies are presented highlighting the current limitations in the development of an effective rhBMP delivery system applicable in clinical bone tissue engineering.

Original language	English
Pages (from-to)	1817-1824
Number of pages	8
Journal	Biotechnology Letters
Volume	31
Issue number	12
Early online date	19 Aug 2009
DOIs	https://doi.org/10.1007/s10529-009-0099-x
State	Published - Nov 2009
Externally published	Yes

Bibliographical note

Keywords

Bone morphogenetic proteins
Bone regeneration
Bone repair
Craniofacial surgery
Delivery systems
Orthopaedics

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10.1007/s10529-009-0099-x

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title = "Delivery of recombinant bone morphogenetic proteins for bone regeneration and repair. Part A: Current challenges in BMP delivery",

abstract = "Recombinant human bone morphogenetic proteins (rhBMPs) have been extensively investigated for developing therapeutic strategies aimed at the restoration and treatment of orthopaedic as well as craniofacial conditions. In this first part of the review, we discuss the rationale for the necessary use of carrier systems to deliver rhBMP-2 and rhBMP-7 to sites of bone tissue regeneration and repair. General requirements for growth factor delivery systems emphasizing the distinction between localized and release-controlled delivery strategies are presented highlighting the current limitations in the development of an effective rhBMP delivery system applicable in clinical bone tissue engineering.",

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AB - Recombinant human bone morphogenetic proteins (rhBMPs) have been extensively investigated for developing therapeutic strategies aimed at the restoration and treatment of orthopaedic as well as craniofacial conditions. In this first part of the review, we discuss the rationale for the necessary use of carrier systems to deliver rhBMP-2 and rhBMP-7 to sites of bone tissue regeneration and repair. General requirements for growth factor delivery systems emphasizing the distinction between localized and release-controlled delivery strategies are presented highlighting the current limitations in the development of an effective rhBMP delivery system applicable in clinical bone tissue engineering.

KW - Bone morphogenetic proteins

KW - Bone regeneration

KW - Bone repair

KW - Craniofacial surgery

KW - Delivery systems

KW - Orthopaedics

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Delivery of recombinant bone morphogenetic proteins for bone regeneration and repair. Part A: Current challenges in BMP delivery

Abstract

Bibliographical note

Keywords

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