Delivery of recombinant bone morphogenetic proteins for bone regeneration and repair. Part B: Delivery systems for BMPs in orthopaedic and craniofacial tissue engineering

Ziyad S. Haidar; Reggie C. Hamdy; Maryam Tabrizian

doi:10.1007/s10529-009-0100-8

Delivery of recombinant bone morphogenetic proteins for bone regeneration and repair. Part B: Delivery systems for BMPs in orthopaedic and craniofacial tissue engineering

Ziyad S. Haidar, Reggie C. Hamdy, Maryam Tabrizian^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

163 Scopus citations

Abstract

Localized and release-controlled delivery systems for the sustained expression of the biologic potency of rhBMPs are essential. A substantial number of biomaterials have been investigated thus far. Most fail after implantation or administration mainly due to either being too soft, difficult to control and/or stabilize mechanically. In the second part of this review, we review a representative selection of rhBMP-2 and rhBMP-7 carrier materials and delivery systems ranging from simple nano/microparticles to complex 3-D scaffolds in sites of orthopaedic and craniofacial bone regeneration and repair.

Original language	English
Pages (from-to)	1825-1835
Number of pages	11
Journal	Biotechnology Letters
Volume	31
Issue number	12
DOIs	https://doi.org/10.1007/s10529-009-0100-8
State	Published - Nov 2009
Externally published	Yes

Keywords

Biomaterials
Bone morphogenetic proteins
Bone regeneration
Controlled-release
Nanoparticles
Synthetic polymers

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10.1007/s10529-009-0100-8

Cite this

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title = "Delivery of recombinant bone morphogenetic proteins for bone regeneration and repair. Part B: Delivery systems for BMPs in orthopaedic and craniofacial tissue engineering",

abstract = "Localized and release-controlled delivery systems for the sustained expression of the biologic potency of rhBMPs are essential. A substantial number of biomaterials have been investigated thus far. Most fail after implantation or administration mainly due to either being too soft, difficult to control and/or stabilize mechanically. In the second part of this review, we review a representative selection of rhBMP-2 and rhBMP-7 carrier materials and delivery systems ranging from simple nano/microparticles to complex 3-D scaffolds in sites of orthopaedic and craniofacial bone regeneration and repair.",

keywords = "Biomaterials, Bone morphogenetic proteins, Bone regeneration, Controlled-release, Nanoparticles, Synthetic polymers",

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Delivery of recombinant bone morphogenetic proteins for bone regeneration and repair. Part B: Delivery systems for BMPs in orthopaedic and craniofacial tissue engineering. / Haidar, Ziyad S.; Hamdy, Reggie C.; Tabrizian, Maryam.
In: Biotechnology Letters, Vol. 31, No. 12, 11.2009, p. 1825-1835.

Research output: Contribution to journal › Review article › peer-review

TY - JOUR

T1 - Delivery of recombinant bone morphogenetic proteins for bone regeneration and repair. Part B

T2 - Delivery systems for BMPs in orthopaedic and craniofacial tissue engineering

AU - Haidar, Ziyad S.

AU - Hamdy, Reggie C.

AU - Tabrizian, Maryam

PY - 2009/11

Y1 - 2009/11

N2 - Localized and release-controlled delivery systems for the sustained expression of the biologic potency of rhBMPs are essential. A substantial number of biomaterials have been investigated thus far. Most fail after implantation or administration mainly due to either being too soft, difficult to control and/or stabilize mechanically. In the second part of this review, we review a representative selection of rhBMP-2 and rhBMP-7 carrier materials and delivery systems ranging from simple nano/microparticles to complex 3-D scaffolds in sites of orthopaedic and craniofacial bone regeneration and repair.

AB - Localized and release-controlled delivery systems for the sustained expression of the biologic potency of rhBMPs are essential. A substantial number of biomaterials have been investigated thus far. Most fail after implantation or administration mainly due to either being too soft, difficult to control and/or stabilize mechanically. In the second part of this review, we review a representative selection of rhBMP-2 and rhBMP-7 carrier materials and delivery systems ranging from simple nano/microparticles to complex 3-D scaffolds in sites of orthopaedic and craniofacial bone regeneration and repair.

KW - Biomaterials

KW - Bone morphogenetic proteins

KW - Bone regeneration

KW - Controlled-release

KW - Nanoparticles

KW - Synthetic polymers

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JO - Biotechnology Letters

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Delivery of recombinant bone morphogenetic proteins for bone regeneration and repair. Part B: Delivery systems for BMPs in orthopaedic and craniofacial tissue engineering

Abstract

Keywords

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