Abstract
Localized and release-controlled delivery systems for the sustained expression of the biologic potency of rhBMPs are essential. A substantial number of biomaterials have been investigated thus far. Most fail after implantation or administration mainly due to either being too soft, difficult to control and/or stabilize mechanically. In the second part of this review, we review a representative selection of rhBMP-2 and rhBMP-7 carrier materials and delivery systems ranging from simple nano/microparticles to complex 3-D scaffolds in sites of orthopaedic and craniofacial bone regeneration and repair.
Original language | English |
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Pages (from-to) | 1825-1835 |
Number of pages | 11 |
Journal | Biotechnology Letters |
Volume | 31 |
Issue number | 12 |
Early online date | 19 Aug 2009 |
DOIs | |
State | Published - Nov 2009 |
Externally published | Yes |
Bibliographical note
© Copyright 2010 Elsevier B.V., All rights reserved.Keywords
- Biomaterials
- Bone morphogenetic proteins
- Bone regeneration
- Controlled-release
- Nanoparticles
- Synthetic polymers