Delivery of recombinant bone morphogenetic proteins for bone regeneration and repair. Part A: Current challenges in BMP delivery

Ziyad S. Haidar, Reggie C. Hamdy, Maryam Tabrizian

Research output: Contribution to journalScientific reviewpeer-review

175 Scopus citations

Abstract

Recombinant human bone morphogenetic proteins (rhBMPs) have been extensively investigated for developing therapeutic strategies aimed at the restoration and treatment of orthopaedic as well as craniofacial conditions. In this first part of the review, we discuss the rationale for the necessary use of carrier systems to deliver rhBMP-2 and rhBMP-7 to sites of bone tissue regeneration and repair. General requirements for growth factor delivery systems emphasizing the distinction between localized and release-controlled delivery strategies are presented highlighting the current limitations in the development of an effective rhBMP delivery system applicable in clinical bone tissue engineering.
Original languageAmerican English
Pages (from-to)1817-1824
Number of pages8
JournalBiotechnology Letters
Volume31
Issue number12
DOIs
StatePublished - 1 Nov 2009
Externally publishedYes

Keywords

  • Bone morphogenetic proteins
  • Bone regeneration
  • Bone repair
  • Craniofacial surgery
  • Delivery systems
  • Orthopaedics

Fingerprint Dive into the research topics of 'Delivery of recombinant bone morphogenetic proteins for bone regeneration and repair. Part A: Current challenges in BMP delivery'. Together they form a unique fingerprint.

Cite this