Delivery of recombinant bone morphogenetic proteins for bone regeneration and repair. Part B: Delivery systems for BMPs in orthopaedic and craniofacial tissue engineering

Ziyad S. Haidar, Reggie C. Hamdy, Maryam Tabrizian

Research output: Contribution to journalScientific reviewpeer-review

128 Scopus citations

Abstract

Localized and release-controlled delivery systems for the sustained expression of the biologic potency of rhBMPs are essential. A substantial number of biomaterials have been investigated thus far. Most fail after implantation or administration mainly due to either being too soft, difficult to control and/or stabilize mechanically. In the second part of this review, we review a representative selection of rhBMP-2 and rhBMP-7 carrier materials and delivery systems ranging from simple nano/microparticles to complex 3-D scaffolds in sites of orthopaedic and craniofacial bone regeneration and repair.
Original languageAmerican English
Pages (from-to)1825-1835
Number of pages11
JournalBiotechnology Letters
Volume31
Issue number12
DOIs
StatePublished - 1 Nov 2009
Externally publishedYes

Keywords

  • Biomaterials
  • Bone morphogenetic proteins
  • Bone regeneration
  • Controlled-release
  • Nanoparticles
  • Synthetic polymers

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