Del macro al microcarcinoma tiroideo: Cambios en las características de presentación del cáncer de tiroides en un centro universitario chileno en 20 años

Translated title of the contribution: From macro to micro thyroid carcinoma: Records of a clinical hospital from 1991 to 2010

Lorena Mosso*, Claudia Campusano, Hernán González, José Miguel Domínguez, Patricio Salman, Valeria Suazo, Antonieta Solar, Jaime Cerda

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Background: The prevalence of thyroid cancer has increased, particularly in nodules smaller than 10 mm, probably due to the growing use of routine thyroid ultrasound. There is controversy about the biological behavior of microcarcinomas and the relevance of their early detection. Aim: To characterize the clinical presentation of thyroid cancer over 20 years in an University medical center and to evaluate the differences between macro and microcarcinomas. Patients and Methods: We reviewed 1547 surgical biopsy records of thyroid cancer in our institution obtained between 1991 and 2010. Results: We observed a sustained increase in the rate of thyroidectomies for thyroid cancer (per 1000 surgical procedures) in the study period. Papillary, follicular, mixed, medullary and anaplastic carcinomas were observed in 95, 3, 2, 0.5 and 0.1% of biopsies, respectively. The incidence of tumors of less than 10 mm (microcarcinoma) also increased. Those findings were associated with a significant decrease in tumor aggressiveness, determined by a low frequency of surgical margin involvement of thyroid capsule, perithyroid tissue invasion, vascular permeation and lymph node metastases. Conclusions: The increased prevalence of thyroid cancer, especially of microcarcinomas, may reflect the greater use of diagnostic ultrasound or represent a real change in the biological behavior of this disease and our data suggest that further studies are needed to know the impact of early treatment in the outcome of those patients because of the real less histologyc agressiveness of microcarcinomas.

Translated title of the contributionFrom macro to micro thyroid carcinoma: Records of a clinical hospital from 1991 to 2010
Original languageSpanish
Pages (from-to)442-448
Number of pages7
JournalRevista Medica de Chile
Issue number4
StatePublished - Apr 2013
Externally publishedYes


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