Crosstalk between Body Microbiota and the Regulation of Immunity

Carolina Rojas, Felipe Gálvez-Jirón, Javiera De Solminihac, Cristina Padilla, Ignacio Cárcamo, Natalia Villalón, Mónica Kurte, Karina Pino-Lagos*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations


The microbiome corresponds to the genetic component of microorganisms (archaea, bacteria, phages, viruses, fungi, and protozoa) that coexist with an individual. During the last two decades, research on this topic has become massive demonstrating that in both homeostasis and disease, the microbiome plays an important role, and in some cases, a decisive one. To date, microbiota have been identified at different body locations, such as the eyes, lung, gastrointestinal and genitourinary tracts, and skin, and technological advances have permitted the taxonomic characterization of resident species and their metabolites, in addition to the cellular and molecular components of the host that maintain a crosstalk with local microorganisms. Here, we summarize recent studies regarding microbiota residing in different zones of the body and their relationship with the immune system. We emphasize the immune components underlying pathological conditions and how they interact with local (and distant) microbiota.

Original languageEnglish
Article number6274265
JournalJournal of Immunology Research
StatePublished - 19 May 2022

Bibliographical note

Copyright © 2022 Carolina Rojas et al.


  • Bacteria
  • Gastrointestinal Microbiome
  • Homeostasis
  • Immune System
  • Microbiota


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