Molecular orchestration: In the directed evolution of a hyperthermally stabilized enzyme, remote residues have been structurally coupled as a result of the creation of an extensive communicating amino acid network on the surface of the protein.
|Number of pages||5|
|Journal||Angewandte Chemie - International Edition|
|State||Published - 19 Oct 2009|
- Directed evolution
- Hydrogen bonds
- Protein modifications
- Saturation mutagenesis