Abstract
Mesenchymal stem cells (MSCs) can trans/differentiate to neural precursors and/or mature neurons and promote neuroprotection and neurogenesis. The above could greatly benefit neurodegenerative disorders as well as in the treatment of post-traumatic and hereditary diseases of the central nervous system (CNS). In order to attain an ideal source of adult MSCs for the treatment of CNS diseases, adipose tissue, bone marrow, skin and umbilical cord derived MSCs were isolated and studied to explore differences with regard to neural differentiation capacity. In this study, we demonstrated that MSCs from several tissues can differentiate into neuron-like cells and differentially express progenitors and mature neural markers. Adipose tissue MSCs exhibited significantly higher expression of neural markers and had a faster proliferation rate. Our results suggest that adipose tissue MSCs are the best candidates for the use in neurological diseases.
| Original language | English |
|---|---|
| Article number | e0213032 |
| Journal | PLoS ONE |
| Volume | 14 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 2019 |
| Externally published | Yes |
Bibliographical note
Funding Information:This study was supported by RM-13IEAT-20943 from innova Corfo, https://www. corfo.cl/, CJ, and PI2013-DA001 from Academic Direction of Clinica Las Condes, www. clinicalascondes.cl.
Publisher Copyright:
Copyright: © 2019 Urrutia et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Keywords
- Adipose Tissue
- Adult
- Bone Marrow Cells
- Cell Proliferation
- Cell- and Tissue-Based Therapy
- Cells, Cultured
- Central Nervous System Diseases
- Chile
- Female
- Humans
- Male
- Mesenchymal Stem Cells
- Nerve Regeneration
- Neurogenesis
- Primary Cell Culture
- Regenerative Medicine
- Skin
- Umbilical Cord
- Young Adult