Primary sclerosing cholangitis and inflammatory bowel disease: Intestine-liver interrelation

Paulina Núñez F.; Rodrigo Quera P.; Fernando Gomollón

doi:10.1016/j.gastrohep.2019.02.004

Primary sclerosing cholangitis and inflammatory bowel disease: Intestine-liver interrelation

Translated title of the contribution: Primary sclerosing cholangitis and inflammatory bowel disease: Intestine-liver interrelation

Paulina Núñez F.^*
, Rodrigo Quera P.
, Fernando Gomollón

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

24 Scopus citations

Abstract

The association between inflammatory bowel disease (IBD)and primary sclerosing cholangitis should be considered a distinct clinical entity. This association involves genetic abnormalities, epidemiological factors (more common in men, with no a geographical pattern)and, commonly, subclinical inflammation, predominance of the right colon (endoscopic and histological), backwash ileitis and rectal sparing. Furthermore, there is an increased risk of colorectal cancer and cholangiocarcinoma. The aim of this review is to show how IBD influences the progression of this entity, transplantation requirements and recurrence. We also discuss the current evidence on the use of biological therapy in this group of patients.

Translated title of the contribution	Primary sclerosing cholangitis and inflammatory bowel disease: Intestine-liver interrelation
Original language	English
Pages (from-to)	316-325
Number of pages	10
Journal	Gastroenterologia y Hepatologia
Volume	42
Issue number	5
DOIs	https://doi.org/10.1016/j.gastrohep.2019.02.004
State	Published - May 2019
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2019 Elsevier España, S.L.U.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Crohn's disease
Inflammatory bowel disease
Primary sclerosing cholangitis
Ulcerative colitis

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10.1016/j.gastrohep.2019.02.004

Cite this

@article{58e599a3b200440497eba85543db085a,

title = "Primary sclerosing cholangitis and inflammatory bowel disease: Intestine-liver interrelation",

abstract = "The association between inflammatory bowel disease (IBD)and primary sclerosing cholangitis should be considered a distinct clinical entity. This association involves genetic abnormalities, epidemiological factors (more common in men, with no a geographical pattern)and, commonly, subclinical inflammation, predominance of the right colon (endoscopic and histological), backwash ileitis and rectal sparing. Furthermore, there is an increased risk of colorectal cancer and cholangiocarcinoma. The aim of this review is to show how IBD influences the progression of this entity, transplantation requirements and recurrence. We also discuss the current evidence on the use of biological therapy in this group of patients.",

keywords = "Crohn's disease, Inflammatory bowel disease, Primary sclerosing cholangitis, Ulcerative colitis",

author = "\{N{\'u}{\~n}ez F.\}, Paulina and \{Quera P.\}, Rodrigo and Fernando Gomoll{\'o}n",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Espa{\~n}a, S.L.U.",

year = "2019",

month = may,

doi = "10.1016/j.gastrohep.2019.02.004",

language = "English",

volume = "42",

pages = "316--325",

journal = "Gastroenterologia y Hepatologia",

issn = "0210-5705",

publisher = "Ediciones Doyma, S.L.",

number = "5",

}

TY - JOUR

T1 - Primary sclerosing cholangitis and inflammatory bowel disease

T2 - Intestine-liver interrelation

AU - Núñez F., Paulina

AU - Quera P., Rodrigo

AU - Gomollón, Fernando

PY - 2019/5

Y1 - 2019/5

N2 - The association between inflammatory bowel disease (IBD)and primary sclerosing cholangitis should be considered a distinct clinical entity. This association involves genetic abnormalities, epidemiological factors (more common in men, with no a geographical pattern)and, commonly, subclinical inflammation, predominance of the right colon (endoscopic and histological), backwash ileitis and rectal sparing. Furthermore, there is an increased risk of colorectal cancer and cholangiocarcinoma. The aim of this review is to show how IBD influences the progression of this entity, transplantation requirements and recurrence. We also discuss the current evidence on the use of biological therapy in this group of patients.

AB - The association between inflammatory bowel disease (IBD)and primary sclerosing cholangitis should be considered a distinct clinical entity. This association involves genetic abnormalities, epidemiological factors (more common in men, with no a geographical pattern)and, commonly, subclinical inflammation, predominance of the right colon (endoscopic and histological), backwash ileitis and rectal sparing. Furthermore, there is an increased risk of colorectal cancer and cholangiocarcinoma. The aim of this review is to show how IBD influences the progression of this entity, transplantation requirements and recurrence. We also discuss the current evidence on the use of biological therapy in this group of patients.

KW - Crohn's disease

KW - Inflammatory bowel disease

KW - Primary sclerosing cholangitis

KW - Ulcerative colitis

UR - https://www.scopus.com/pages/publications/85063618398

U2 - 10.1016/j.gastrohep.2019.02.004

DO - 10.1016/j.gastrohep.2019.02.004

M3 - Review article

C2 - 30948141

AN - SCOPUS:85063618398

SN - 0210-5705

VL - 42

SP - 316

EP - 325

JO - Gastroenterologia y Hepatologia

JF - Gastroenterologia y Hepatologia

IS - 5

ER -

Primary sclerosing cholangitis and inflammatory bowel disease: Intestine-liver interrelation

Abstract

Bibliographical note

UN SDGs

Keywords

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