Coarse Particulate Air Pollution and Daily Mortality A Global Study in 205 Cities

Cong Liu; Jing Cai; Renjie Chen; Francesco Sera; Yuming Guo; Shilu Tong; Shanshan Li; Eric Lavigne; Patricia Matus Correa; Nicolas Valdes Ortega; Hans Orru; Marek Maasikmets; Jouni J.K. Jaakkola; Niilo Ryti; Susanne Breitner; Alexandra Schneider; Klea Katsouyanni; Evangelia Samoli; Masahiro Hashizume; Yasushi Honda; Chris Fook Sheng Ng; Magali Hurtado Diaz; César De la Cruz Valencia; Shilpa Rao; Alfonso Diz Lois Palomares; Susana Pereira da Silva; Joana Madureira; Iulian Horia Holobâc; Simona Fratianni; Noah Scovronick; Rebecca M. Garland; Aurelio Tobias; Carmén Iñiguez; Bertil Forsberg; Christofer Åstrom; Ana Maria Vicedo-Cabrera; Martina S. Ragettli; Yue Liang Leon Guo; Shih Chun Pan; Ai Milojevic; Michelle L. Bell; Antonella Zanobetti; Joel Schwartz; Antonio Gasparrini; Haidong Kan

doi:10.1164/rccm.202111-2657OC

Coarse Particulate Air Pollution and Daily Mortality A Global Study in 205 Cities

Cong Liu, Jing Cai, Renjie Chen, Francesco Sera, Yuming Guo, Shilu Tong, Shanshan Li, Eric Lavigne, Patricia Matus Correa, Nicolas Valdes Ortega, Hans Orru, Marek Maasikmets, Jouni J.K. Jaakkola, Niilo Ryti, Susanne Breitner, Alexandra Schneider, Klea Katsouyanni, Evangelia Samoli, Masahiro Hashizume, Yasushi HondaChris Fook Sheng Ng, Magali Hurtado Diaz, César De la Cruz Valencia, Shilpa Rao, Alfonso Diz Lois Palomares, Susana Pereira da Silva, Joana Madureira, Iulian Horia Holobâc, Simona Fratianni, Noah Scovronick, Rebecca M. Garland, Aurelio Tobias, Carmén Iñiguez, Bertil Forsberg, Christofer Åstrom, Ana Maria Vicedo-Cabrera, Martina S. Ragettli, Yue Liang Leon Guo, Shih Chun Pan, Ai Milojevic, Michelle L. Bell, Antonella Zanobetti, Joel Schwartz, Antonio Gasparrini, Haidong Kan^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

Rationale: The associations between ambient coarse particulate matter (PM_2.5–10) and daily mortality are not fully understood on a global scale. Objectives: To evaluate the short-term associations between PM_2.5–10 and total, cardiovascular, and respiratory mortality across multiple countries/regions worldwide. Methods: We collected daily mortality (total, cardiovascular, and respiratory) and air pollution data from 205 cities in 20 countries/regions. Concentrations of PM_2.5–10 were computed as the difference between inhalable and fine PM. A two-stage time-series analytic approach was applied, with overdispersed generalized linear models and multilevel meta-analysis. We fitted two-pollutant models to test the independent effect of PM_2.5–10 from copollutants (fine PM, nitrogen dioxide, sulfur dioxide, ozone, and carbon monoxide). Exposure–response relationship curves were pooled, and regional analyses were conducted. Measurements and Main Results: A 10 μg/m³ increase in PM_2.5–10 concentration on lag 0–1 day was associated with increments of 0.51% (95% confidence interval [CI], 0.18%–0.84%), 0.43% (95% CI, 0.15%–0.71%), and 0.41% (95% CI, 0.06%–0.77%) in total, cardiovascular, and respiratory mortality, respectively. The associations varied by country and region. These associations were robust to adjustment by all copollutants in two-pollutant models, especially for PM_2.5. The exposure–response curves for total, cardiovascular, and respiratory mortality were positive, with steeper slopes at lower exposure ranges and without discernible thresholds. Conclusions: This study provides novel global evidence on the robust and independent associations between short-term exposure to ambient PM_2.5–10 and total, cardiovascular, and respiratory mortality, suggesting the need to establish a unique guideline or regulatory limit for daily concentrations of PM_2.5–10

Original language	English
Pages (from-to)	999-1007
Number of pages	9
Journal	American Journal of Respiratory and Critical Care Medicine
Volume	206
Issue number	8
DOIs	https://doi.org/10.1164/rccm.202111-2657OC
State	Published - 1 Oct 2022

Bibliographical note

Publisher Copyright:
Copyright © 2022 by the American Thoracic Society.

Keywords

air pollution
mortality
multicenter study
PM
time-series study

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1164/rccm.202111-2657OC

Cite this

Liu, C., Cai, J., Chen, R., Sera, F., Guo, Y., Tong, S., Li, S., Lavigne, E., Correa, P. M., Ortega, N. V., Orru, H., Maasikmets, M., Jaakkola, J. J. K., Ryti, N., Breitner, S., Schneider, A., Katsouyanni, K., Samoli, E., Hashizume, M., ... Kan, H. (2022). Coarse Particulate Air Pollution and Daily Mortality A Global Study in 205 Cities. American Journal of Respiratory and Critical Care Medicine, 206(8), 999-1007. https://doi.org/10.1164/rccm.202111-2657OC

@article{579442de90a147268abaec2e27d46e35,

title = "Coarse Particulate Air Pollution and Daily Mortality A Global Study in 205 Cities",

abstract = "Rationale: The associations between ambient coarse particulate matter (PM2.5–10) and daily mortality are not fully understood on a global scale. Objectives: To evaluate the short-term associations between PM2.5–10 and total, cardiovascular, and respiratory mortality across multiple countries/regions worldwide. Methods: We collected daily mortality (total, cardiovascular, and respiratory) and air pollution data from 205 cities in 20 countries/regions. Concentrations of PM2.5–10 were computed as the difference between inhalable and fine PM. A two-stage time-series analytic approach was applied, with overdispersed generalized linear models and multilevel meta-analysis. We fitted two-pollutant models to test the independent effect of PM2.5–10 from copollutants (fine PM, nitrogen dioxide, sulfur dioxide, ozone, and carbon monoxide). Exposure–response relationship curves were pooled, and regional analyses were conducted. Measurements and Main Results: A 10 μg/m3 increase in PM2.5–10 concentration on lag 0–1 day was associated with increments of 0.51% (95% confidence interval [CI], 0.18%–0.84%), 0.43% (95% CI, 0.15%–0.71%), and 0.41% (95% CI, 0.06%–0.77%) in total, cardiovascular, and respiratory mortality, respectively. The associations varied by country and region. These associations were robust to adjustment by all copollutants in two-pollutant models, especially for PM2.5. The exposure–response curves for total, cardiovascular, and respiratory mortality were positive, with steeper slopes at lower exposure ranges and without discernible thresholds. Conclusions: This study provides novel global evidence on the robust and independent associations between short-term exposure to ambient PM2.5–10 and total, cardiovascular, and respiratory mortality, suggesting the need to establish a unique guideline or regulatory limit for daily concentrations of PM2.5–10",

keywords = "air pollution, mortality, multicenter study, PM, time-series study",

author = "Cong Liu and Jing Cai and Renjie Chen and Francesco Sera and Yuming Guo and Shilu Tong and Shanshan Li and Eric Lavigne and Correa, {Patricia Matus} and Ortega, {Nicolas Valdes} and Hans Orru and Marek Maasikmets and Jaakkola, {Jouni J.K.} and Niilo Ryti and Susanne Breitner and Alexandra Schneider and Klea Katsouyanni and Evangelia Samoli and Masahiro Hashizume and Yasushi Honda and Ng, {Chris Fook Sheng} and Diaz, {Magali Hurtado} and {De la Cruz Valencia}, C{\'e}sar and Shilpa Rao and Palomares, {Alfonso Diz Lois} and {da Silva}, {Susana Pereira} and Joana Madureira and Holob{\^a}c, {Iulian Horia} and Simona Fratianni and Noah Scovronick and Garland, {Rebecca M.} and Aurelio Tobias and Carm{\'e}n I{\~n}iguez and Bertil Forsberg and Christofer {\AA}strom and Vicedo-Cabrera, {Ana Maria} and Ragettli, {Martina S.} and Guo, {Yue Liang Leon} and Pan, {Shih Chun} and Ai Milojevic and Bell, {Michelle L.} and Antonella Zanobetti and Joel Schwartz and Antonio Gasparrini and Haidong Kan",

note = "Publisher Copyright: Copyright {\textcopyright} 2022 by the American Thoracic Society.",

year = "2022",

month = oct,

day = "1",

doi = "10.1164/rccm.202111-2657OC",

language = "English",

volume = "206",

pages = "999--1007",

journal = "American Journal of Respiratory and Critical Care Medicine",

issn = "1073-449X",

publisher = "American Thoracic Society",

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Liu, C, Cai, J, Chen, R, Sera, F, Guo, Y, Tong, S, Li, S, Lavigne, E, Correa, PM, Ortega, NV, Orru, H, Maasikmets, M, Jaakkola, JJK, Ryti, N, Breitner, S, Schneider, A, Katsouyanni, K, Samoli, E, Hashizume, M, Honda, Y, Ng, CFS, Diaz, MH, De la Cruz Valencia, C, Rao, S, Palomares, ADL, da Silva, SP, Madureira, J, Holobâc, IH, Fratianni, S, Scovronick, N, Garland, RM, Tobias, A, Iñiguez, C, Forsberg, B, Åstrom, C, Vicedo-Cabrera, AM, Ragettli, MS, Guo, YLL, Pan, SC, Milojevic, A, Bell, ML, Zanobetti, A, Schwartz, J, Gasparrini, A & Kan, H 2022, 'Coarse Particulate Air Pollution and Daily Mortality A Global Study in 205 Cities', American Journal of Respiratory and Critical Care Medicine, vol. 206, no. 8, pp. 999-1007. https://doi.org/10.1164/rccm.202111-2657OC

TY - JOUR

T1 - Coarse Particulate Air Pollution and Daily Mortality A Global Study in 205 Cities

AU - Liu, Cong

AU - Cai, Jing

AU - Chen, Renjie

AU - Sera, Francesco

AU - Guo, Yuming

AU - Tong, Shilu

AU - Li, Shanshan

AU - Lavigne, Eric

AU - Correa, Patricia Matus

AU - Ortega, Nicolas Valdes

AU - Orru, Hans

AU - Maasikmets, Marek

AU - Jaakkola, Jouni J.K.

AU - Ryti, Niilo

AU - Breitner, Susanne

AU - Schneider, Alexandra

AU - Katsouyanni, Klea

AU - Samoli, Evangelia

AU - Hashizume, Masahiro

AU - Honda, Yasushi

AU - Ng, Chris Fook Sheng

AU - Diaz, Magali Hurtado

AU - De la Cruz Valencia, César

AU - Rao, Shilpa

AU - Palomares, Alfonso Diz Lois

AU - da Silva, Susana Pereira

AU - Madureira, Joana

AU - Holobâc, Iulian Horia

AU - Fratianni, Simona

AU - Scovronick, Noah

AU - Garland, Rebecca M.

AU - Tobias, Aurelio

AU - Iñiguez, Carmén

AU - Forsberg, Bertil

AU - Åstrom, Christofer

AU - Vicedo-Cabrera, Ana Maria

AU - Ragettli, Martina S.

AU - Guo, Yue Liang Leon

AU - Pan, Shih Chun

AU - Milojevic, Ai

AU - Bell, Michelle L.

AU - Zanobetti, Antonella

AU - Schwartz, Joel

AU - Gasparrini, Antonio

AU - Kan, Haidong

PY - 2022/10/1

Y1 - 2022/10/1

N2 - Rationale: The associations between ambient coarse particulate matter (PM2.5–10) and daily mortality are not fully understood on a global scale. Objectives: To evaluate the short-term associations between PM2.5–10 and total, cardiovascular, and respiratory mortality across multiple countries/regions worldwide. Methods: We collected daily mortality (total, cardiovascular, and respiratory) and air pollution data from 205 cities in 20 countries/regions. Concentrations of PM2.5–10 were computed as the difference between inhalable and fine PM. A two-stage time-series analytic approach was applied, with overdispersed generalized linear models and multilevel meta-analysis. We fitted two-pollutant models to test the independent effect of PM2.5–10 from copollutants (fine PM, nitrogen dioxide, sulfur dioxide, ozone, and carbon monoxide). Exposure–response relationship curves were pooled, and regional analyses were conducted. Measurements and Main Results: A 10 μg/m3 increase in PM2.5–10 concentration on lag 0–1 day was associated with increments of 0.51% (95% confidence interval [CI], 0.18%–0.84%), 0.43% (95% CI, 0.15%–0.71%), and 0.41% (95% CI, 0.06%–0.77%) in total, cardiovascular, and respiratory mortality, respectively. The associations varied by country and region. These associations were robust to adjustment by all copollutants in two-pollutant models, especially for PM2.5. The exposure–response curves for total, cardiovascular, and respiratory mortality were positive, with steeper slopes at lower exposure ranges and without discernible thresholds. Conclusions: This study provides novel global evidence on the robust and independent associations between short-term exposure to ambient PM2.5–10 and total, cardiovascular, and respiratory mortality, suggesting the need to establish a unique guideline or regulatory limit for daily concentrations of PM2.5–10

AB - Rationale: The associations between ambient coarse particulate matter (PM2.5–10) and daily mortality are not fully understood on a global scale. Objectives: To evaluate the short-term associations between PM2.5–10 and total, cardiovascular, and respiratory mortality across multiple countries/regions worldwide. Methods: We collected daily mortality (total, cardiovascular, and respiratory) and air pollution data from 205 cities in 20 countries/regions. Concentrations of PM2.5–10 were computed as the difference between inhalable and fine PM. A two-stage time-series analytic approach was applied, with overdispersed generalized linear models and multilevel meta-analysis. We fitted two-pollutant models to test the independent effect of PM2.5–10 from copollutants (fine PM, nitrogen dioxide, sulfur dioxide, ozone, and carbon monoxide). Exposure–response relationship curves were pooled, and regional analyses were conducted. Measurements and Main Results: A 10 μg/m3 increase in PM2.5–10 concentration on lag 0–1 day was associated with increments of 0.51% (95% confidence interval [CI], 0.18%–0.84%), 0.43% (95% CI, 0.15%–0.71%), and 0.41% (95% CI, 0.06%–0.77%) in total, cardiovascular, and respiratory mortality, respectively. The associations varied by country and region. These associations were robust to adjustment by all copollutants in two-pollutant models, especially for PM2.5. The exposure–response curves for total, cardiovascular, and respiratory mortality were positive, with steeper slopes at lower exposure ranges and without discernible thresholds. Conclusions: This study provides novel global evidence on the robust and independent associations between short-term exposure to ambient PM2.5–10 and total, cardiovascular, and respiratory mortality, suggesting the need to establish a unique guideline or regulatory limit for daily concentrations of PM2.5–10

KW - air pollution

KW - mortality

KW - multicenter study

KW - PM

KW - time-series study

UR - http://www.scopus.com/inward/record.url?scp=85140144957&partnerID=8YFLogxK

U2 - 10.1164/rccm.202111-2657OC

DO - 10.1164/rccm.202111-2657OC

M3 - Article

C2 - 35671471

AN - SCOPUS:85140144957

SN - 1073-449X

VL - 206

SP - 999

EP - 1007

JO - American Journal of Respiratory and Critical Care Medicine

JF - American Journal of Respiratory and Critical Care Medicine

IS - 8

ER -

Coarse Particulate Air Pollution and Daily Mortality A Global Study in 205 Cities

Abstract

Bibliographical note

Keywords

UN SDGs

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