Clinical and molecular features of cardial gastric cancer associated to Epstein Barr virus

Alejandro Corvalán R, Suminori Akiba, María Teresa Valenzuela B, Miguel Angel Cumsille G, Chihaya Koriyama, Jorge Argandoña C, Claudia Backhouse E, Matilde Bal C, Fernando Mena U, Mariana Palma V, Yoshito Eizuru

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Background: Mortality caused by cardial gastric cancer in Chile, is increasing. Previously we demonstrated an association between Epstein Barr virus and this specific location of gastric cancer. Aim: To perform a clinical and molecular characterization of cardial gastric cancer associated to Epstein Barr virus. Material and methods: Epstein Barr virus was identified in 93 cardial gastric tumors, by in situ hybridization. Clinical and pathological features, survival and expression of p53 and c-erbB2 were compared between tumors with or without the presence of the virus. Results: Twenty two (23.6%) tumors expressed Epstein Barr virus. No difference in sex or age of patients with tumors positive or negative for the virus was observed. Epstein Barr positive tumors had a tendency to have a higher frequency of Bormann III endoscopic appearance and a lower frequency of p53 accumulation (p=0.06). Five years survival was 67% and 42% of tumors positive and negative for the presence of the virus, respectively (p=0.57). Conclusions: Our results, although not significant, show a tendency towards unique characteristics of cardial gastric tumors associated to Epstein Barr virus.
Original languageAmerican English
Pages (from-to)753-760
Number of pages8
JournalRevista Medica de Chile
Issue number7
StatePublished - 22 Nov 2005
Externally publishedYes


  • Epstein-Barr virus infections
  • Herpes virus 4, human
  • Stomach neoplasms

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