Circumscribed palmar or plantar hypokeratosis: A distinctive epidermal malformation of the palms or soles

Amparo Pérez*, Arno Rütten, Reinhard Gold, Francisco Urbina, Carlos Misad, Maria José Izquierdo, Celia Requena, Adolfo Aliaga, Heinz Kutzner, Luis Requena

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

112 Scopus citations


Background: Epidermal malformations of the skin include a group of heterogeneous developmental defects that result from errors in morphogenesis of the epidermis during intrauterine life. Objective: The purpose of this study was to report the clinical and histopathologic features of a distinctive epidermal malformation involving the skin of the palms or soles. Methods: Ten patients were included in this study. All of them showed the same clinical features that consisted of a solitary circumscribed and circular area of erythematous depressed skin on the palm or on the sole. Diagnosis was confirmed by histopathologic study. Results: All patients were middle aged or elderly. Nine patients were women and one was a man. The lesions showed predilection for the skin of the thenar and hypothenar regions of the palm or the medial side of the sole. Histopathologic study demonstrated a depression of the epidermis, with a sharp stair between normal and involved skin. The epidermis covering the depression showed markedly thinner horny layer and a slightly diminished granular cell layer when compared with adjacent noninvolved skin. Keratinocytes of the squamous cell layer, granular cells, and corneocytes showed, otherwise, a normal appearance. Serial sections failed to demonstrate cornoid lamellation. Conclusion: On the basis of the clinical and histopathologic findings in these 10 patients, we have named this malformation circumscribed palmar or plantar hypokeratosis. This lesion seems to be a distinctive entity that has not been previously described.

Original languageEnglish
Pages (from-to)21-27
Number of pages7
JournalJournal of the American Academy of Dermatology
Issue number1
StatePublished - 1 Jul 2002
Externally publishedYes


  • Adult
  • Aged
  • Article
  • Clinical article
  • Clinical feature
  • Female
  • Histopathology
  • Human
  • Human tissue
  • Keratinocyte
  • Keratosis palmaris
  • Keratosis palmoplantaris
  • Male
  • Nomenclature
  • Priority journal
  • Skin manifestation
  • Squamous cell
  • Tumor localization


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