Chilean pilot study on the risk of lung cancer associated with codon 72 polymorphism in the gene of protein p53

Carlos Ernesto Irarrazabal Muñoz, Claudio Rojas, Rosa Aracena, Carola Márquez, Lionel Gil

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

The p53 gene has a polymorphism at codon 72 that presents the arginine or proline genotype, although this polymorphism has been associated with genetically determined susceptibility to lung cancers, the literature has not been consistent with this association. In Chile lung cancer represents the second cause of mortality from cancer. p53 codon 72 polymorphism frequency was studied in a Chilean subpopulation of 133 healthy controls and 111 lung cancer patients. The allelic distribution of the three genotypes (ArgArg, ArgPro, ProPro) in healthy normal controls was 41, 44 and 15%, respectively, which differs slightly from that of lung cancer patients, which was 38, 40 and 22%. A relation between the presence of the Pro allele and lung cancer risk in male smokers was observed. Relative risks were O.R.=2.47 (95% CI: 1.34-4.54) for one single nucleotide polymorphic allele (Pro) and O.R.=3.88 (95% CI: 1.16-13.39) for ProPro genotype.

Original languageEnglish
Pages (from-to)69-76
Number of pages8
JournalToxicology Letters
Volume144
Issue number1
DOIs
StatePublished - 15 Sep 2003
Externally publishedYes

Bibliographical note

Funding Information:
This research was financed by FONDECYT grants, numbers 2990019 and 1000628 and by European Community INCO project Number 972631. We thank Dr Alvaro Undurraga from the ‘Hospital del Tórax’ for his collaboration in obtaining blood samples from patients. This work has been carried out in accordance with the Chilean Biosafety and Ethical Scientific Research Regulations.

Keywords

  • Lung cancer risk
  • p53 codon 72
  • PCR-RFLP
  • Polymorphism

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