Characterization of a Gelatin/chitosan/hyaluronan scaffold-polymer

Javier Enrione, Fernando Osorio, Daniel López, Caroline Weinstein-Oppenheimer, Miguel A. Fuentes, Ricardo Ceriani, Donald I. Brown, Fernando Albornoz, Elizabeth Sánchez, Patricio Villalobos, Rodrigo A. Somoza, Manuel E. Young, Cristian A. Acevedo

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Gelatin, chitosan and hyaluronic acid are natural components used to prepare polymeric scaffold in tissue engineering. The physical properties of these materials confer an appropriate microenvironment for cells, which can be used as a regeneration system for skin and cartilage. In this work, we prepared and characterized a Gelatin/Chitosan/Hyaluronan lyophilized-polymer. Physical properties of lyophilized-polymer changed slightly with moisture, but when polymer was totally hydrated the elasticity changed significantly. Thermophysical characterisation indicated that temperatures higher than 30° could modify irreversibly the polymeric matrix probably due to protein denaturation. Besides, we used the polymer as scaffold to prepare a biosynthetic-skin, reporting biological behaviour and its mechanical properties.
Original languageAmerican English
JournalElectronic Journal of Biotechnology
Volume13
Issue number5
DOIs
StatePublished - 1 Dec 2010
Externally publishedYes

Keywords

  • Chitosan
  • Fibrin
  • Gelatin
  • Hyaluronic acid
  • Scaffold

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