Change in consumption patterns for treatment-seeking patients with alcohol use disorder post-bariatric surgery

Alfredo B. Cuellar-Barboza, Mark A. Frye, Karen Grothe, Miguel L. Prieto, Terry D. Schneekloth, Larissa L. Loukianova, K. Hall Flavin Daniel, Matthew M. Clark, Victor M. Karpyak, Joseph D. Miller, Osama A. Abulseoud

Research output: Contribution to journalReview articlepeer-review

33 Scopus citations


The aim of this study is to describe the clinical phenotype of alcohol use disorder (AUD) treatment-seeking patients with Roux-en-Y Gastric Bypass Surgery (RYGB) history; and to compare it to AUD obese non-RYGB controls. Methods: Retrospective study of electronic medical records for all patients 30-60. years treated at the Mayo Clinic Addiction Treatment Program, between June, 2004 and July, 2012. Comparisons were performed with consumption patterns pre-RYGB and at time of treatment; excluding patients with AUD treatments pre-RYGB. Results: Forty-one out of 823 patients had a RYGB history (4.9%); 122 controls were selected. Compared to controls, the RYGB group had significantly more females [. n = 29 (70.7%) vs. n = 35 (28.7%) p < 0.0001]; and met AUD criteria at a significantly earlier age (19.1 ± 0.4 vs. 25.0 ± 1. years old, p = 0.002). On average, RYGB patients reported resuming alcohol consumption 1.4 ± 0.2. years post-surgery, meeting criteria for AUD at 3.1 ± 0.5. years and seeking treatment at 5.4 ± 0.3. years postoperatively. Pre-surgical drinks per day were significantly fewer compared to post-surgical consumption [2.5 ± 0.4 vs. 8.1 ± 1.3, p = 0.009]. Prior to admission, RYGB patients reported fewer drinking days per week vs. controls (4.7 ± 0.3 vs. 5.5 ± 1.8. days, p = 0.02). Neither RYGB, gender, age nor BMI was associated with differential drinking patterns. Conclusion: The results of this study suggest that some patients develop progressive AUD several years following RYGB. This observation has important clinical implications, calling for AUD-preventive measures following RYGB. Further large-scale longitudinal studies are needed to clarify the association between RYGB and AUD onset.

Original languageEnglish
Pages (from-to)199-204
Number of pages6
JournalJournal of Psychosomatic Research
Issue number3
StatePublished - 1 Mar 2015

Bibliographical note

Funding Information:
OAA conceived and designed the study. ABCB and OAA collected and verified the data. JDM, MLP, ABCB and OAA performed statistical analysis, and prepared the figures; OAA and ABCB wrote the manuscript. All authors contributed significantly to interpreting the data, reviewing and editing the manuscript. This work has been funded by an NIH/NCRR CTSA KL2 ( RR024151 ) grant to OAA.

Funding Information:
Dr. Frye has received grant support from AssureRx Health , Myriad , Pfizer , National Institute of Mental Health ( RO1 MH079261 ), National Institute of Alcohol Abuse and Alcoholism ( P20AA017830 ), Mayo Foundation ; has been a consultant to Janssen Global Services, LLC, Mitsubishi Tanabe Pharma Corporation, Myriad, Sunovion, and Teva Pharmaceuticals; and has received CME/Travel Support/presentation from CME Outfitters Inc. and Sunovian.

Publisher Copyright:
© 2014 Elsevier Inc.


  • Alcohol use disorder
  • Bariatric surgery
  • Relapse
  • Roux-en-Y gastric bypass (RYGB)


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