Change in consumption patterns for treatment-seeking patients with alcohol use disorder post-bariatric surgery

Alfredo B. Cuellar-Barboza; Mark A. Frye; Karen Grothe; Miguel L. Prieto; Terry D. Schneekloth; Larissa L. Loukianova; K. Hall Flavin Daniel; Matthew M. Clark; Victor M. Karpyak; Joseph D. Miller; Osama A. Abulseoud

doi:10.1016/j.jpsychores.2014.06.019

Change in consumption patterns for treatment-seeking patients with alcohol use disorder post-bariatric surgery

Alfredo B. Cuellar-Barboza, Mark A. Frye, Karen Grothe, Miguel L. Prieto, Terry D. Schneekloth, Larissa L. Loukianova, K. Hall Flavin Daniel, Matthew M. Clark, Victor M. Karpyak, Joseph D. Miller, Osama A. Abulseoud^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

40 Scopus citations

Abstract

The aim of this study is to describe the clinical phenotype of alcohol use disorder (AUD) treatment-seeking patients with Roux-en-Y Gastric Bypass Surgery (RYGB) history; and to compare it to AUD obese non-RYGB controls. Methods: Retrospective study of electronic medical records for all patients 30-60. years treated at the Mayo Clinic Addiction Treatment Program, between June, 2004 and July, 2012. Comparisons were performed with consumption patterns pre-RYGB and at time of treatment; excluding patients with AUD treatments pre-RYGB. Results: Forty-one out of 823 patients had a RYGB history (4.9%); 122 controls were selected. Compared to controls, the RYGB group had significantly more females [. n = 29 (70.7%) vs. n = 35 (28.7%) p < 0.0001]; and met AUD criteria at a significantly earlier age (19.1 ± 0.4 vs. 25.0 ± 1. years old, p = 0.002). On average, RYGB patients reported resuming alcohol consumption 1.4 ± 0.2. years post-surgery, meeting criteria for AUD at 3.1 ± 0.5. years and seeking treatment at 5.4 ± 0.3. years postoperatively. Pre-surgical drinks per day were significantly fewer compared to post-surgical consumption [2.5 ± 0.4 vs. 8.1 ± 1.3, p = 0.009]. Prior to admission, RYGB patients reported fewer drinking days per week vs. controls (4.7 ± 0.3 vs. 5.5 ± 1.8. days, p = 0.02). Neither RYGB, gender, age nor BMI was associated with differential drinking patterns. Conclusion: The results of this study suggest that some patients develop progressive AUD several years following RYGB. This observation has important clinical implications, calling for AUD-preventive measures following RYGB. Further large-scale longitudinal studies are needed to clarify the association between RYGB and AUD onset.

Original language	English
Pages (from-to)	199-204
Number of pages	6
Journal	Journal of Psychosomatic Research
Volume	78
Issue number	3
DOIs	https://doi.org/10.1016/j.jpsychores.2014.06.019
State	Published - 1 Mar 2015

Bibliographical note

Funding Information:
OAA conceived and designed the study. ABCB and OAA collected and verified the data. JDM, MLP, ABCB and OAA performed statistical analysis, and prepared the figures; OAA and ABCB wrote the manuscript. All authors contributed significantly to interpreting the data, reviewing and editing the manuscript. This work has been funded by an NIH/NCRR CTSA KL2 ( RR024151 ) grant to OAA.

Funding Information:
Dr. Frye has received grant support from AssureRx Health , Myriad , Pfizer , National Institute of Mental Health ( RO1 MH079261 ), National Institute of Alcohol Abuse and Alcoholism ( P20AA017830 ), Mayo Foundation ; has been a consultant to Janssen Global Services, LLC, Mitsubishi Tanabe Pharma Corporation, Myriad, Sunovion, and Teva Pharmaceuticals; and has received CME/Travel Support/presentation from CME Outfitters Inc. and Sunovian.

Publisher Copyright:
© 2014 Elsevier Inc.

Keywords

Alcohol use disorder
Bariatric surgery
Relapse
Roux-en-Y gastric bypass (RYGB)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jpsychores.2014.06.019

Cite this

Cuellar-Barboza, A. B., Frye, M. A., Grothe, K., Prieto, M. L., Schneekloth, T. D., Loukianova, L. L., Daniel, K. H. F., Clark, M. M., Karpyak, V. M., Miller, J. D., & Abulseoud, O. A. (2015). Change in consumption patterns for treatment-seeking patients with alcohol use disorder post-bariatric surgery. Journal of Psychosomatic Research, 78(3), 199-204. https://doi.org/10.1016/j.jpsychores.2014.06.019

@article{344f5071aedb457180f3c8651efa2121,

title = "Change in consumption patterns for treatment-seeking patients with alcohol use disorder post-bariatric surgery",

abstract = "The aim of this study is to describe the clinical phenotype of alcohol use disorder (AUD) treatment-seeking patients with Roux-en-Y Gastric Bypass Surgery (RYGB) history; and to compare it to AUD obese non-RYGB controls. Methods: Retrospective study of electronic medical records for all patients 30-60. years treated at the Mayo Clinic Addiction Treatment Program, between June, 2004 and July, 2012. Comparisons were performed with consumption patterns pre-RYGB and at time of treatment; excluding patients with AUD treatments pre-RYGB. Results: Forty-one out of 823 patients had a RYGB history (4.9%); 122 controls were selected. Compared to controls, the RYGB group had significantly more females [. n = 29 (70.7%) vs. n = 35 (28.7%) p < 0.0001]; and met AUD criteria at a significantly earlier age (19.1 ± 0.4 vs. 25.0 ± 1. years old, p = 0.002). On average, RYGB patients reported resuming alcohol consumption 1.4 ± 0.2. years post-surgery, meeting criteria for AUD at 3.1 ± 0.5. years and seeking treatment at 5.4 ± 0.3. years postoperatively. Pre-surgical drinks per day were significantly fewer compared to post-surgical consumption [2.5 ± 0.4 vs. 8.1 ± 1.3, p = 0.009]. Prior to admission, RYGB patients reported fewer drinking days per week vs. controls (4.7 ± 0.3 vs. 5.5 ± 1.8. days, p = 0.02). Neither RYGB, gender, age nor BMI was associated with differential drinking patterns. Conclusion: The results of this study suggest that some patients develop progressive AUD several years following RYGB. This observation has important clinical implications, calling for AUD-preventive measures following RYGB. Further large-scale longitudinal studies are needed to clarify the association between RYGB and AUD onset.",

keywords = "Alcohol use disorder, Bariatric surgery, Relapse, Roux-en-Y gastric bypass (RYGB)",

author = "Cuellar-Barboza, {Alfredo B.} and Frye, {Mark A.} and Karen Grothe and Prieto, {Miguel L.} and Schneekloth, {Terry D.} and Loukianova, {Larissa L.} and Daniel, {K. Hall Flavin} and Clark, {Matthew M.} and Karpyak, {Victor M.} and Miller, {Joseph D.} and Abulseoud, {Osama A.}",

note = "Funding Information: OAA conceived and designed the study. ABCB and OAA collected and verified the data. JDM, MLP, ABCB and OAA performed statistical analysis, and prepared the figures; OAA and ABCB wrote the manuscript. All authors contributed significantly to interpreting the data, reviewing and editing the manuscript. This work has been funded by an NIH/NCRR CTSA KL2 ( RR024151 ) grant to OAA. Funding Information: Dr. Frye has received grant support from AssureRx Health , Myriad , Pfizer , National Institute of Mental Health ( RO1 MH079261 ), National Institute of Alcohol Abuse and Alcoholism ( P20AA017830 ), Mayo Foundation ; has been a consultant to Janssen Global Services, LLC, Mitsubishi Tanabe Pharma Corporation, Myriad, Sunovion, and Teva Pharmaceuticals; and has received CME/Travel Support/presentation from CME Outfitters Inc. and Sunovian. Publisher Copyright: {\textcopyright} 2014 Elsevier Inc.",

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doi = "10.1016/j.jpsychores.2014.06.019",

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Cuellar-Barboza, AB, Frye, MA, Grothe, K, Prieto, ML, Schneekloth, TD, Loukianova, LL, Daniel, KHF, Clark, MM, Karpyak, VM, Miller, JD & Abulseoud, OA 2015, 'Change in consumption patterns for treatment-seeking patients with alcohol use disorder post-bariatric surgery', Journal of Psychosomatic Research, vol. 78, no. 3, pp. 199-204. https://doi.org/10.1016/j.jpsychores.2014.06.019

TY - JOUR

T1 - Change in consumption patterns for treatment-seeking patients with alcohol use disorder post-bariatric surgery

AU - Cuellar-Barboza, Alfredo B.

AU - Frye, Mark A.

AU - Grothe, Karen

AU - Prieto, Miguel L.

AU - Schneekloth, Terry D.

AU - Loukianova, Larissa L.

AU - Daniel, K. Hall Flavin

AU - Clark, Matthew M.

AU - Karpyak, Victor M.

AU - Miller, Joseph D.

AU - Abulseoud, Osama A.

N1 - Funding Information: OAA conceived and designed the study. ABCB and OAA collected and verified the data. JDM, MLP, ABCB and OAA performed statistical analysis, and prepared the figures; OAA and ABCB wrote the manuscript. All authors contributed significantly to interpreting the data, reviewing and editing the manuscript. This work has been funded by an NIH/NCRR CTSA KL2 ( RR024151 ) grant to OAA. Funding Information: Dr. Frye has received grant support from AssureRx Health , Myriad , Pfizer , National Institute of Mental Health ( RO1 MH079261 ), National Institute of Alcohol Abuse and Alcoholism ( P20AA017830 ), Mayo Foundation ; has been a consultant to Janssen Global Services, LLC, Mitsubishi Tanabe Pharma Corporation, Myriad, Sunovion, and Teva Pharmaceuticals; and has received CME/Travel Support/presentation from CME Outfitters Inc. and Sunovian. Publisher Copyright: © 2014 Elsevier Inc.

PY - 2015/3/1

Y1 - 2015/3/1

N2 - The aim of this study is to describe the clinical phenotype of alcohol use disorder (AUD) treatment-seeking patients with Roux-en-Y Gastric Bypass Surgery (RYGB) history; and to compare it to AUD obese non-RYGB controls. Methods: Retrospective study of electronic medical records for all patients 30-60. years treated at the Mayo Clinic Addiction Treatment Program, between June, 2004 and July, 2012. Comparisons were performed with consumption patterns pre-RYGB and at time of treatment; excluding patients with AUD treatments pre-RYGB. Results: Forty-one out of 823 patients had a RYGB history (4.9%); 122 controls were selected. Compared to controls, the RYGB group had significantly more females [. n = 29 (70.7%) vs. n = 35 (28.7%) p < 0.0001]; and met AUD criteria at a significantly earlier age (19.1 ± 0.4 vs. 25.0 ± 1. years old, p = 0.002). On average, RYGB patients reported resuming alcohol consumption 1.4 ± 0.2. years post-surgery, meeting criteria for AUD at 3.1 ± 0.5. years and seeking treatment at 5.4 ± 0.3. years postoperatively. Pre-surgical drinks per day were significantly fewer compared to post-surgical consumption [2.5 ± 0.4 vs. 8.1 ± 1.3, p = 0.009]. Prior to admission, RYGB patients reported fewer drinking days per week vs. controls (4.7 ± 0.3 vs. 5.5 ± 1.8. days, p = 0.02). Neither RYGB, gender, age nor BMI was associated with differential drinking patterns. Conclusion: The results of this study suggest that some patients develop progressive AUD several years following RYGB. This observation has important clinical implications, calling for AUD-preventive measures following RYGB. Further large-scale longitudinal studies are needed to clarify the association between RYGB and AUD onset.

AB - The aim of this study is to describe the clinical phenotype of alcohol use disorder (AUD) treatment-seeking patients with Roux-en-Y Gastric Bypass Surgery (RYGB) history; and to compare it to AUD obese non-RYGB controls. Methods: Retrospective study of electronic medical records for all patients 30-60. years treated at the Mayo Clinic Addiction Treatment Program, between June, 2004 and July, 2012. Comparisons were performed with consumption patterns pre-RYGB and at time of treatment; excluding patients with AUD treatments pre-RYGB. Results: Forty-one out of 823 patients had a RYGB history (4.9%); 122 controls were selected. Compared to controls, the RYGB group had significantly more females [. n = 29 (70.7%) vs. n = 35 (28.7%) p < 0.0001]; and met AUD criteria at a significantly earlier age (19.1 ± 0.4 vs. 25.0 ± 1. years old, p = 0.002). On average, RYGB patients reported resuming alcohol consumption 1.4 ± 0.2. years post-surgery, meeting criteria for AUD at 3.1 ± 0.5. years and seeking treatment at 5.4 ± 0.3. years postoperatively. Pre-surgical drinks per day were significantly fewer compared to post-surgical consumption [2.5 ± 0.4 vs. 8.1 ± 1.3, p = 0.009]. Prior to admission, RYGB patients reported fewer drinking days per week vs. controls (4.7 ± 0.3 vs. 5.5 ± 1.8. days, p = 0.02). Neither RYGB, gender, age nor BMI was associated with differential drinking patterns. Conclusion: The results of this study suggest that some patients develop progressive AUD several years following RYGB. This observation has important clinical implications, calling for AUD-preventive measures following RYGB. Further large-scale longitudinal studies are needed to clarify the association between RYGB and AUD onset.

KW - Alcohol use disorder

KW - Bariatric surgery

KW - Relapse

KW - Roux-en-Y gastric bypass (RYGB)

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DO - 10.1016/j.jpsychores.2014.06.019

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SN - 0022-3999

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SP - 199

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JO - Journal of Psychosomatic Research

JF - Journal of Psychosomatic Research

IS - 3

ER -

Change in consumption patterns for treatment-seeking patients with alcohol use disorder post-bariatric surgery

Abstract

Bibliographical note

Keywords

UN SDGs

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