Cardiotoxicity of anticancer therapies. Towards the implementation of cardio-oncology units

René Hameau, Luigi Gabrielli, Marcelo Garrido, Ana María Guzmán, Ignacio Retamal, María José Vacarezza, Douglas Greig, Mauricio Ocqueteau, César Sánchez, Marcela Pizarro, Alejandro Corvalán, Sergio Lavandero, Pablo F. Castro, Gonzalo Martínez*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Recently, we have witnessed major improvements in cancer treatment. Early diagnosis and development of new therapies have reduced cancer-related mortality. However, these new therapies, along with greater patient survival, are associated with an increase in untoward effects, particularly in the cardiovascular system. Although cardiotoxicity induced by oncologic treatments affects predominantly the myocardium, it can also involve other structures of the cardiovascular system, becoming one of the main causes of morbidity and mortality in those who survive cancer. The main objective of cardio-oncology is to achieve the maximum benefits of oncologic treatments while minimizing their deleterious cardiovascular effects. It harbors the stratification of patients at risk of cardiotoxicity, the implementation of diagnostic tools (imaging techniques and biomarkers) for early diagnosis, preventive strategies and early treatment options for the complications. Herein, we discuss the basic knowledge for the implementation of cardio-oncology units and their role in the management of cancer patients, the diagnostic tools available to detect cardiotoxicity and the present therapeutic options.

Translated title of the contributionCardiotoxicity of anticancer therapies. Towards the implementation of cardio-oncology units
Original languageSpanish
Pages (from-to)68-77
Number of pages10
JournalRevista Medica de Chile
Volume146
Issue number1
DOIs
StatePublished - Jan 2018
Externally publishedYes

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