Brain metastasis in patients with adrenocortical carcinoma: A clinical series

Mauricio Burotto*, Nishant Tageja, Avi Rosenberg, Sowmya Mahalingam, Martha Quezado, Margarita Velarde, Maureen Edgerly, Tito Fojo

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Introduction: Adrenocortical carcinoma (ACC) is a heterogeneous and rare disease. At presentation or at the time of a recurrence, the disease commonly spreads to the liver, lungs, lymph nodes, and bones. The brain has only rarely been reported as a site of metastases. Objective: The aims of this report were to describe the clinical characteristics of patients with ACC who developed brain metastasis and were evaluated at the National Cancer Institute. Methods: We describe the history and clinical presentation of six patients with ACC and metastatic disease in the brain. Images of the six patients and pathology slides were reviewed when available. Results: The median age at the time of the diagnosis of ACC was 42 years. The median time from the initial diagnosis until the presentation of brain metastasis was 43 months. As a group the patients had previously received multiples lines of chemotherapy (median of three), and they presented with one to three metastatic brain lesions. Four patients underwent metastasectomy, one had radiosurgery, and one had both modalities. Two patients are still alive, three died, between 2 and 14 months after the diagnosis of brain metastases, and one was lost to follow-up. Conclusion: Patients with advanced ACC can rarely present with metastasis to the brain, most often long after the initial diagnosis. Timely diagnosis of brain metastasis with appropriate intervention after discussion in a multidisciplinary meeting can improve the prognosis in this particular scenario.

Original languageEnglish
Pages (from-to)331-336
Number of pages6
JournalJournal of Clinical Endocrinology and Metabolism
Issue number2
StatePublished - 1 Feb 2015
Externally publishedYes

Bibliographical note

Publisher Copyright:
Copyright © 2015 by the Endocrine Society.


  • Adrenal Cortex Neoplasms
  • Adrenocortical Carcinoma
  • Adult
  • Brain
  • Brain Neoplasms
  • Female
  • Humans
  • Male
  • Middle Aged
  • Prognosis


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