Brain-Derived Neurotrophic Factor (BDNF) as a Predictor of Treatment Response in Major Depressive Disorder (MDD): A Systematic Review

Mario Ignacio Zelada; Verónica Garrido; Andrés Liberona; Natalia Jones; Karen Zúñiga; Hernán Silva; Rodrigo R. Nieto

doi:10.3390/ijms241914810

Brain-Derived Neurotrophic Factor (BDNF) as a Predictor of Treatment Response in Major Depressive Disorder (MDD): A Systematic Review

Mario Ignacio Zelada, Verónica Garrido, Andrés Liberona, Natalia Jones, Karen Zúñiga, Hernán Silva, Rodrigo R. Nieto^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

29 Scopus citations

Abstract

Brain-derived neurotrophic factor (BDNF) has been studied as a biomarker of major depressive disorder (MDD). Besides diagnostic biomarkers, clinically useful biomarkers can inform response to treatment. We aimed to review all studies that sought to relate BDNF baseline levels, or BDNF polymorphisms, with response to treatment in MDD. In order to achieve this, we performed a systematic review of studies that explored the relation of BDNF with both pharmacological and non-pharmacological treatment. Finally, we reviewed the evidence that relates peripheral levels of BDNF and BDNF polymorphisms with the development and management of treatment-resistant depression.

Original language	English
Article number	14810
Journal	International Journal of Molecular Sciences
Volume	24
Issue number	19
DOIs	https://doi.org/10.3390/ijms241914810
State	Published - Oct 2023
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2023 by the authors.

Keywords

BDNF
biomarkers
major depression
major depressive disorder
neurotrophins
treatment refractoriness
treatment resistance
treatment response
treatment-resistant depression

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10.3390/ijms241914810

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title = "Brain-Derived Neurotrophic Factor (BDNF) as a Predictor of Treatment Response in Major Depressive Disorder (MDD): A Systematic Review",

abstract = "Brain-derived neurotrophic factor (BDNF) has been studied as a biomarker of major depressive disorder (MDD). Besides diagnostic biomarkers, clinically useful biomarkers can inform response to treatment. We aimed to review all studies that sought to relate BDNF baseline levels, or BDNF polymorphisms, with response to treatment in MDD. In order to achieve this, we performed a systematic review of studies that explored the relation of BDNF with both pharmacological and non-pharmacological treatment. Finally, we reviewed the evidence that relates peripheral levels of BDNF and BDNF polymorphisms with the development and management of treatment-resistant depression.",

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AU - Liberona, Andrés

AU - Jones, Natalia

AU - Zúñiga, Karen

AU - Silva, Hernán

AU - Nieto, Rodrigo R.

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KW - biomarkers

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KW - neurotrophins

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Brain-Derived Neurotrophic Factor (BDNF) as a Predictor of Treatment Response in Major Depressive Disorder (MDD): A Systematic Review

Abstract

Bibliographical note

Keywords

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