Biomarkers in early-stage non-small-cell lung cancer: Current concepts and future directions

Mauricio Burotto, Anish Thomas, Deepa Subramaniam, Giuseppe Giaccone, Arun Rajan*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

44 Scopus citations

Abstract

Advances in molecular biology and bioinformatics have resulted in the identification of a number of potential biomarkers that could be relevant in the management of patients with non-small-cell lung cancer (NSCLC). Although there is an increasing amount of literature related to these biomarkers, major issues need to be resolved including validity and reproducibility of results. Additionally, in order to interpret the existing literature accurately, a clear distinction must be made between the prognostic and predictive value of biomarkers. The practical applicability of biomarker discovery for patients with lung cancer includes the identification of patients with early-stage NSCLC who are most likely to benefit from adjuvant therapy. Information gleaned from biomarkers has the potential to help in evaluating the role of targeted therapies including immunotherapy in the neoadjuvant and adjuvant setting. The role of gene signatures and the use of newer platforms such as RNA, methylation, and protein signatures is being explored in patients with early-stage NSCLC. This review focuses on the applications of biomarker discovery in patients with early-stage NSCLC.

Original languageEnglish
Pages (from-to)1609-1617
Number of pages9
JournalJournal of Thoracic Oncology
Volume9
Issue number11
DOIs
StatePublished - 1 Nov 2014
Externally publishedYes

Bibliographical note

Funding Information:
Supported by Intramural Program, National Cancer Institute, National Institutes of Health.

Publisher Copyright:
© 2014 by the International Association for the Study of Lung Cancer.

Keywords

  • Biomarkers
  • Early-stage lung cancer
  • Lung cancer
  • Predictive
  • Prognostic

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