Bacterial endotoxin and tumor necrosis factor stimulate prostaglandin production by human decidua

R. Romero*, M. Mazor, Y. K. Wu, C. Avila, E. Oyarzun, M. D. Mitchell

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

118 Scopus citations


The purpose of these studies was to determine the effect of bacterial endotoxin and tumor necrosis factor (TNF) on prostaglandin (PG) secretion by human decidua. Decidual explants were established from women undergoing elective cesarean sections before the onset of labor. Escherichia Coli endotoxin and purified human recombinant TNF (rhTNF) were incubated with decidual explants. PGF and PGF2 biosynthesis was measured by radioimmunoassay. A significant increase in the release of all PGs into the media occurred in response to LPS and TNF. In the setting of an extraamniotic infection, bacterial and host secretory products (TNF) could trigger the onset of labor, activating the decidua to produce PGs.

Original languageEnglish
Pages (from-to)183-186
Number of pages4
JournalProstaglandins Leukotrienes and Essential Fatty Acids
Issue number3
StatePublished - Sep 1989
Externally publishedYes

Bibliographical note

Funding Information:
These studies were partially supported hy a grant from the Walter Scott Foundation for Medical Research and by NIH Grant HD 2t17-17. Dr. Roberto Romcro is a recipient of a Phvs~ci~ln Scientist Award from the National Institutes ttf Ch>ld Heaith and Human Development. (Reprint requests to RR). Yale University School of Medicine Department of Obstetrics and Gynecology 333 Cedar Street. P.O. Box 333.3 New Haven. Connecticut 06510. USA


  • Decidua
  • Dinoprost
  • Dinoprostone
  • Endotoxins
  • Escherichia coli
  • Female
  • Human
  • Pregnancy
  • Support, Non-U.S. Gov't
  • Support, U.S. Gov't, P.H.S.
  • Tumor necrosis factor


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