Bacterial endotoxin and tumor necrosis factor stimulate prostaglandin production by human decidua

R. Romero, M. Mazor, Y. K. Wu, C. Avila, E. Oyarzun, M. D. Mitchell

Research output: Contribution to journalArticlepeer-review

113 Scopus citations

Abstract

The purpose of these studies was to determine the effect of bacterial endotoxin and tumor necrosis factor (TNF) on prostaglandin (PG) secretion by human decidua. Decidual explants were established from women undergoing elective cesarean sections before the onset of labor. Escherichia Coli endotoxin and purified human recombinant TNF (rhTNF) were incubated with decidual explants. PGF2α and PGF2 biosynthesis was measured by radioimmunoassay. A significant increase in the release of all PGs into the media occurred in response to LPS and TNF. In the setting of an extraamniotic infection, bacterial and host secretory products (TNF) could trigger the onset of labor, activating the decidua to produce PGs.
Original languageAmerican English
Pages (from-to)183-186
Number of pages4
JournalProstaglandins, Leukotrienes and Essential Fatty Acids
Volume37
Issue number3
DOIs
StatePublished - 1 Jan 1989
Externally publishedYes

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