Abstract

Life stressors can wreak havoc on our health, contributing to mood disorders like major depressive disorder (MDD), a widespread and debilitating condition. Unfortunately, current treatments and diagnostic strategies fall short of addressing these disorders, highlighting the need for new approaches. In this regard, the relationship between MDD, brain inflammation (neuroinflammation), and systemic inflammation in the body may offer novel insights. Recent research has uncovered the crucial role of astrocytes in coordinating the inflammatory response through the release of extracellular vesicles (ADEVs) during different neuroinflammatory conditions. While the contribution of ADEVs to stress and MDD remains largely unexplored, their potential to modulate immune cells and contribute to MDD pathogenesis is significant. In this article, we delve into the immunomodulatory role of ADEVs, their potential impact on peripheral immune cells, and how their microRNA (miRNA) landscape may hold the key to controlling immune cell activity. Together, these mechanisms may constitute an opportunity to develop novel therapeutic pharmacological approaches to tackle mood disorders.

Original languageEnglish
Article number106833
JournalPharmacological Research
Volume194
DOIs
StatePublished - Aug 2023

Bibliographical note

Publisher Copyright:
© 2023 The Authors

Keywords

  • Astrocyte
  • Extracellular vesicles
  • Immune response
  • Major depressive disorder
  • Neuroinflammation
  • miRNA

Fingerprint

Dive into the research topics of 'Astrocyte-derived extracellular vesicles in stress-associated mood disorders. Does the immune system get astrocytic?'. Together they form a unique fingerprint.

Cite this