Association of Single-Nucleotide Polymorphisms in IL28B, but Not TNF-α, with Severity of Disease Caused by Andes Virus

Jenniffer Angulo, Karla Pino, Natalia Echeverría-Chagas, Claudia Marco, Constanza Martínez-Valdebenito, Hector Galeno, Eliecer Villagra, Lilian Vera, Natalia Lagos, Natalia Becerra, Judith Mora, Andrea Bermúdez, Marcela Cárcamo, Janepsy Díaz, Juan Francisco Miquel, Marcela Ferres, Marcelo López-Lastra

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Background. Andes virus (ANDV) is the sole etiologic agent of hantavirus cardiopulmonary syndrome (HCPS) in Chile, with a fatality rate of about 35%. Individual host factors affecting ANDV infection outcome are poorly understood. In this case-control genetic association analysis, we explored the link between single-nucleotide polymorphisms (SNPs) rs12979860, rs8099917 and rs1800629 and the clinical outcome of ANDV-induced disease. The SNPs rs12979860 and rs8099917 are known to play a role in the differential expression of the interleukin 28B gene (IL28B), whereas SNP rs1800629 is implicated in the expression of tumor necrosis factor α gene (TNF-α). Methods. A total of 238 samples from confirmed ANDV-infected patients collected between 2006 and 2014, and categorized according to the severity of the disease, were genotyped for SNPs rs12979860, rs8099917, and rs1800629. Results. Analysis of IL28B SNPs rs12979860 and rs8099917 revealed a link between homozygosity of the minor alleles (TT and GG, respectively), displaying a mild disease progression, whereas heterozygosity or homozygosity for the major alleles (CT/CC and TG/TT, respectively) in both IL28B SNPs is associated with severe disease. No association with the clinical outcome of HCPS was observed for TNF-α SNP rs1800629 (TNF -308G>A). Conclusions. The IL28B SNPs rs12979860 and rs8099917, but not TNF-α SNP rs1800629, are associated with the clinical outcome of ANDV-induced disease, suggesting a possible link between IL28B expression and ANDV pathogenesis.

Original languageEnglish
Pages (from-to)e62-e69
JournalClinical Infectious Diseases
Volume61
Issue number12
DOIs
StatePublished - 15 Dec 2015
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2015 The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.

Keywords

  • ANDV
  • HCPS
  • IL28B
  • SNP
  • TNF-alpha

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