Association between p53 codon 72 genetic polymorphism and tobacco use and lung cancer risk

Dante D. Cáceres; Luis A. Quiñones; Jane C. Schroeder; Leonel D. Gil; Carlos E. Irarrázabal

doi:10.1007/s00408-008-9133-3

Association between p53 codon 72 genetic polymorphism and tobacco use and lung cancer risk

Dante D. Cáceres
, Luis A. Quiñones
, Jane C. Schroeder
, Leonel D. Gil
, Carlos E. Irarrázabal

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Lung cancer (LCa) is the leading cause of death by cancer in men. Genetic and environmental factors play a synergistic role in its etiology. We explore in 111 lung cancer cases and 133 unrelated noncancer controls the gene-environment interaction (G × E) between p53cd72 polymorphism variants and smoking and the effect on LCa risk in two kinds of case-control designs. We assessed the interaction odds ratio (IOR) using an adjusted unconditional logistic model. We found a significant and positive interaction association between Proallele carriers and smoking habits in both case-control and case-only designs: IOR = 3.90 (95% confidence interval [CI] = 1.10-13.81) and 3.05 (95% CI = 1.63-5.72), respectively. These exploratory results suggest a synergistic effect of the smoking habit and the susceptibility of the Pro allele on lung cancer risk compared with each risk factor alone.

Original language	English
Pages (from-to)	110-115
Number of pages	6
Journal	Lung
Volume	187
Issue number	2
DOIs	https://doi.org/10.1007/s00408-008-9133-3
State	Published - Apr 2009

Bibliographical note

Funding Information:
The National Fund of Scientific Development and Technology (FONDECYT) (Grant No. 2990019) supported this work. Dr. Dante Cáceres thanks Dr. Nevin Schrimshaw and the Ellison Medical Foundation-International Nutrition Foundation.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Case control
Case only
Gene-environment interaction
Genetic polymorphisms
Lung cancer
Risk effect modification
Synergistic effect

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10.1007/s00408-008-9133-3

Cite this

@article{dcc7b658759e486f9b1ea8559f546646,

title = "Association between p53 codon 72 genetic polymorphism and tobacco use and lung cancer risk",

abstract = "Lung cancer (LCa) is the leading cause of death by cancer in men. Genetic and environmental factors play a synergistic role in its etiology. We explore in 111 lung cancer cases and 133 unrelated noncancer controls the gene-environment interaction (G × E) between p53cd72 polymorphism variants and smoking and the effect on LCa risk in two kinds of case-control designs. We assessed the interaction odds ratio (IOR) using an adjusted unconditional logistic model. We found a significant and positive interaction association between Proallele carriers and smoking habits in both case-control and case-only designs: IOR = 3.90 (95\% confidence interval [CI] = 1.10-13.81) and 3.05 (95\% CI = 1.63-5.72), respectively. These exploratory results suggest a synergistic effect of the smoking habit and the susceptibility of the Pro allele on lung cancer risk compared with each risk factor alone.",

keywords = "Case control, Case only, Gene-environment interaction, Genetic polymorphisms, Lung cancer, Risk effect modification, Synergistic effect",

author = "C{\'a}ceres, \{Dante D.\} and Qui{\~n}ones, \{Luis A.\} and Schroeder, \{Jane C.\} and Gil, \{Leonel D.\} and Irarr{\'a}zabal, \{Carlos E.\}",

note = "Funding Information: The National Fund of Scientific Development and Technology (FONDECYT) (Grant No. 2990019) supported this work. Dr. Dante C{\'a}ceres thanks Dr. Nevin Schrimshaw and the Ellison Medical Foundation-International Nutrition Foundation.",

year = "2009",

month = apr,

doi = "10.1007/s00408-008-9133-3",

language = "English",

volume = "187",

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T1 - Association between p53 codon 72 genetic polymorphism and tobacco use and lung cancer risk

AU - Cáceres, Dante D.

AU - Quiñones, Luis A.

AU - Schroeder, Jane C.

AU - Gil, Leonel D.

AU - Irarrázabal, Carlos E.

N1 - Funding Information: The National Fund of Scientific Development and Technology (FONDECYT) (Grant No. 2990019) supported this work. Dr. Dante Cáceres thanks Dr. Nevin Schrimshaw and the Ellison Medical Foundation-International Nutrition Foundation.

PY - 2009/4

Y1 - 2009/4

N2 - Lung cancer (LCa) is the leading cause of death by cancer in men. Genetic and environmental factors play a synergistic role in its etiology. We explore in 111 lung cancer cases and 133 unrelated noncancer controls the gene-environment interaction (G × E) between p53cd72 polymorphism variants and smoking and the effect on LCa risk in two kinds of case-control designs. We assessed the interaction odds ratio (IOR) using an adjusted unconditional logistic model. We found a significant and positive interaction association between Proallele carriers and smoking habits in both case-control and case-only designs: IOR = 3.90 (95% confidence interval [CI] = 1.10-13.81) and 3.05 (95% CI = 1.63-5.72), respectively. These exploratory results suggest a synergistic effect of the smoking habit and the susceptibility of the Pro allele on lung cancer risk compared with each risk factor alone.

AB - Lung cancer (LCa) is the leading cause of death by cancer in men. Genetic and environmental factors play a synergistic role in its etiology. We explore in 111 lung cancer cases and 133 unrelated noncancer controls the gene-environment interaction (G × E) between p53cd72 polymorphism variants and smoking and the effect on LCa risk in two kinds of case-control designs. We assessed the interaction odds ratio (IOR) using an adjusted unconditional logistic model. We found a significant and positive interaction association between Proallele carriers and smoking habits in both case-control and case-only designs: IOR = 3.90 (95% confidence interval [CI] = 1.10-13.81) and 3.05 (95% CI = 1.63-5.72), respectively. These exploratory results suggest a synergistic effect of the smoking habit and the susceptibility of the Pro allele on lung cancer risk compared with each risk factor alone.

KW - Case control

KW - Case only

KW - Gene-environment interaction

KW - Genetic polymorphisms

KW - Lung cancer

KW - Risk effect modification

KW - Synergistic effect

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DO - 10.1007/s00408-008-9133-3

M3 - Article

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AN - SCOPUS:67649126249

SN - 0341-2040

VL - 187

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EP - 115

JO - Lung

JF - Lung

IS - 2

ER -

Association between p53 codon 72 genetic polymorphism and tobacco use and lung cancer risk

Abstract

Bibliographical note

UN SDGs

Keywords

Access to Document

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