Abstract
Lung cancer (LCa) is the leading cause of death by cancer in men. Genetic and environmental factors play a synergistic role in its etiology. We explore in 111 lung cancer cases and 133 unrelated noncancer controls the gene-environment interaction (G × E) between p53cd72 polymorphism variants and smoking and the effect on LCa risk in two kinds of case-control designs. We assessed the interaction odds ratio (IOR) using an adjusted unconditional logistic model. We found a significant and positive interaction association between Proallele carriers and smoking habits in both case-control and case-only designs: IOR = 3.90 (95% confidence interval [CI] = 1.10-13.81) and 3.05 (95% CI = 1.63-5.72), respectively. These exploratory results suggest a synergistic effect of the smoking habit and the susceptibility of the Pro allele on lung cancer risk compared with each risk factor alone.
Original language | English |
---|---|
Pages (from-to) | 110-115 |
Number of pages | 6 |
Journal | Lung |
Volume | 187 |
Issue number | 2 |
DOIs | |
State | Published - Apr 2009 |
Bibliographical note
Funding Information:The National Fund of Scientific Development and Technology (FONDECYT) (Grant No. 2990019) supported this work. Dr. Dante Cáceres thanks Dr. Nevin Schrimshaw and the Ellison Medical Foundation-International Nutrition Foundation.
Keywords
- Case control
- Case only
- Gene-environment interaction
- Genetic polymorphisms
- Lung cancer
- Risk effect modification
- Synergistic effect