Assesment of arterial damage by noninvasive peripheral arterial tonometry in non-diabetic hemodialysis patients

Francisco Espinoza, Sonia Kunstmann, Alvaro Urzúa, Luis Michea, Elisa T. Marusic, Antonio Vukusich

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Background: Hemodialysis patients (HD) display high rates of cardiac disease and mortality. The cardiovascular morbidity and mortality of HD patients is attributable in a signifi cant proportion to endothelial dysfunction, arterial stiffness, and vascular calcifi cations. Aim: To measure vascular reactivity in HD subjects and compare them with healthy volunteers. Material and Methods: Forty eight non diabetic patients aged 58 ± 4.6 years (29 males) on hemodialysis for a mean lapse of 4.8 years were studied. Arterial stiffness was measured in the radial artery. Pulse wave velocity was measured by noninvasive peripheral arterial tonometry in carotid and femoral arteries. Endothelial function was assessed, measuring reactive hyperemia response after a 5 min period of ischemia. As a control, all values were also measured in age and gender-matched healthy volunteers. Results: Arterial stiffness was signifi cantly higher in HD patients than controls (23.9 ± 3.3 and 18.4 ± 3.4% respectively, p < 0.05). HD subjects had an increased pulse wave velocity (10.0 ± 0.8 and 7.6 ± 0.9 m/s respectively, p < 0.05). A reduction in the change in pulse amplitude pressure, as a measure of arterial dysfunction, was only observed in male patients (1.7 ± 0.4 and 2.7 ± 0.4 respectively p < 0.01). Conclusions: Noninvasive assessment of peripheral vascular function may be useful for the identifi cation of patients at risk for late cardiac events.
Original languageAmerican English
Pages (from-to)153-160
Number of pages8
JournalRevista Medica de Chile
Volume140
Issue number2
DOIs
StatePublished - 1 Feb 2012

Keywords

  • Cardiovascular
  • Diagnostic techniques
  • Renal insuffi ciency
  • Vascular diseases

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