Asociación entre periodontitis crónica, interleuquina-6 (IL-6) e índice de masa corporal (IMC) en embarazadas

Translated title of the contribution: Association between chronic periodontitis, interleukin-6 (IL-6) and body mass index (BMI) in pregnant women

Sebastián Mella, c silva, Antonio Sanz, Sebastián Illanes, Flavio Carrión A, Valeria Ramírez, Alejandra Chaparro*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To determine if maternal periodontal clinical status, body mass index (BMI) and its variation during pregnancy are associated with increased levels of interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-) and C-reactive protein (CRP) in plasma. Material and Methods: This clinical study included a total of 56 pregnant women between 18 and 38 years old (mean 27.9 ± 7.04 years), referred from perinatal medicine unit at health care center Universidad de los Andes. All pregnant patients consented to voluntarily participate in the study. In each trimester of pregnancy, they underwent a complete periodontal examination, involving the determination of clinical attachment levels, probing depth, bleeding and hygiene index at six sites of each tooth, excluding third molars. Additionally, in each clinical check, peripheral blood samples were taken for determination of pro-inflammatory mediators with ELISA immunoassay. Periodontal diagnosis and inflammatory mediators were the variables analyzed in relation to changes in BMI during pregnancy. Results: Pregnant women with chronic periodontitis had an increase and more variation of BMI (p=0.039) and higher levels of IL-6 (p=0.026) in comparison with pregnant women with gingivitis. Conclusions: In this series of pregnant patients the clinical diagnosis of periodontitis, with an increase in BMI are associated with increased plasma levels of IL-6 and CRP.
Translated title of the contributionAssociation between chronic periodontitis, interleukin-6 (IL-6) and body mass index (BMI) in pregnant women
Original languageSpanish
Pages (from-to)97-101
Number of pages5
JournalRevista Clínica de Periodoncia, Implantología y Rehabilitación Oral
Volume4
Issue number3
DOIs
StatePublished - Dec 2011

Keywords

  • Gingivitis
  • periodontitis
  • body mass index
  • interleukin-6
  • tumor necrosis factor alpha
  • C reactive protein

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