Antioxidant dysfunctionality of high-density lipoproteins (HDL) in decompensated diabetic patients

Fernanda Awad, Susana Contreras-Duarte, Patricia Molina, Verónica Quiñones, Valentina Serrano, Eduardo Abbott, Alberto Maiz, Dolores Busso, Attilio Rigotti*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Introduction: high density lipoproteins (HDL) have important cardiovascular protective effects mediated by their role in reverse cholesterol transport as well as other functional activities, including significant anti-inflammatory and antioxidant properties. It has been shown that HDL anti-inflammatory and antioxidant functions are defective in metabolically stable diabetic patients; however they have not been evaluated during a hyperglycemic crisis. Aim: to determine the antioxidant activity of HDL during a severe diabetic decompensation and to analyze whether this function is restored after resolution of the acute event. Methods: the antioxidant activity of HDL was measured in vitro by a fluorescent assay in plasma samples obtained from diabetic patients with acute metabolic decompensation at admission, recovery within the hospital and follow-up in ambulatory care. As a comparison, HDL particles from some healthy subjects were used as controls. Results: the HDL antioxidant function was significantly reduced in patients during an acute diabetic decompensation compared with the control group, and was gradually restored reaching normal values during the ambulatory follow-up. Hyperglycemic crisis also showed low plasma paraoxonase-1 activity, which increased significantly during at follow-up. Conclusion: HDL particles isolated from acute diabetic descompensated patients exhibit a significantly and reversibly low antioxidant capacity, which is probably due to a reduced paraoxonase-1 activity.

Translated title of the contributionAntioxidant dysfunctionality of high-density lipoproteins (HDL) in decompensated diabetic patients
Original languageSpanish
Pages (from-to)1131-1138
Number of pages8
JournalNutricion Hospitalaria
Volume32
Issue number3
DOIs
StatePublished - 28 Aug 2015
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2015, Grupo Aula Medica S.A. All rights reserved.

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