Antioxidant dysfunctionality of high-density lipoproteins (HDL) in decompensated diabetic patients

Fernanda Awad, Susana Contreras-Duarte, Patricia Molina, Verónica Quiñones, Valentina Serrano, Eduardo Abbott, Alberto Maiz, Dolores Busso, Attilio Rigotti

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

. All rights reserved. Introduction: high density lipoproteins (HDL) have important cardiovascular protective effects mediated by their role in reverse cholesterol transport as well as other functional activities, including significant anti-inflammatory and antioxidant properties. It has been shown that HDL anti-inflammatory and antioxidant functions are defective in metabolically stable diabetic patients; however they have not been evaluated during a hyperglycemic crisis. Aim: to determine the antioxidant activity of HDL during a severe diabetic decompensation and to analyze whether this function is restored after resolution of the acute event. Methods: the antioxidant activity of HDL was measured in vitro by a fluorescent assay in plasma samples obtained from diabetic patients with acute metabolic decompensation at admission, recovery within the hospital and follow-up in ambulatory care. As a comparison, HDL particles from some healthy subjects were used as controls. Results: the HDL antioxidant function was significantly reduced in patients during an acute diabetic decompensation compared with the control group, and was gradually restored reaching normal values during the ambulatory follow-up. Hyperglycemic crisis also showed low plasma paraoxonase-1 activity, which increased significantly during at follow-up. Conclusion: HDL particles isolated from acute diabetic descompensated patients exhibit a significantly and reversibly low antioxidant capacity, which is probably due to a reduced paraoxonase-1 activity.
Original languageAmerican English
Pages (from-to)1131-1138
Number of pages8
JournalNutricion Hospitalaria
Volume32
Issue number3
DOIs
StatePublished - 1 Jan 2015
Externally publishedYes

Keywords

  • Antioxidant capacity of HDL
  • Diabetes mellitus
  • High density lipoproteins
  • Hyperglycemic crisis
  • Paraoxonase-1

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