Antigenic specificity of lymphocytes isolated from valvular specimens of rheumatic fever patients

Masao Yoshinaga, Fernando Figueroa, Mohammed R. Wahid, R. H. Marcus, Elsa Suh, John B. Zabriskie

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


T cell lines were established from both valvular specimens and peripheral blood lymphocytes from seven patients with well documented rheumatic heart disease. These cell lines were stimulated with either PHA or streptococcal antigens. Proliferation assays revealed that both valvular and peripheral blood T cell lines reacted to cell wall (CW) and cell membrane (CM) antigens obtained from rheumatic fever associated group A streptococci and not to nephritogenic strains. None of the cell lines reacted to M protein, myosin or other mammalian cytoskeletal proteins. The unique reactivity of rheumatic fever T cell lines only to cellular structures obtained from rheumatogenic strains suggests that these lines react to epitopes specific for antigens obtained from these strains.
Original languageAmerican English
Pages (from-to)601-613
Number of pages13
JournalJournal of Autoimmunity
Issue number4
StatePublished - 1 Jan 1995
Externally publishedYes


  • Antigens, Bacterial
  • Bacterial Proteins
  • Cell Line
  • Cell Membrane
  • Cell Wall
  • Epitopes
  • Heart Valves
  • Human; Kinetics
  • Lymphocyte Activation
  • Phytohemagglutinins
  • Rheumatic Fever
  • Species Specificity
  • Streptococcus pyogenes
  • T-Lymphocytes


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