Anticardiolipin antibodies in acute rheumatic fever

Fernando Figueroa*, X. Berrios, M. Gutierrez, F. Carrion, J. Pablo Goycolea, I. Riedel, S. Jacobelli

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

47 Scopus citations


Recent reports describe the association of antiphospholipid antibodies (aPL) with chorea or severe heart valve lesions in systemic lupus erythematosus, lupus-like disease, or the primary antiphospholipid antibody syndrome. We conducted a case series and a case-control investigation of patients with rheumatic fever with Sydenham chorea or other manifestations of rheumatic fever for anticardiolipin antibodies (aCL) during the acute attack and disease remission. Eighty percent of patients were positive for aCL during the rheumatic fever attack vs 40% when inactive (p = 0.035); IgG and IgM aCL increased significantly with disease activity. Individuals with or without Sydenham chorea were equally positive for aCL (76 and 83%, respectively). A significant association was found between IgM aCL and carditis: All patients with valvulitis had IgM aCL (100%) vs 37% of patients without valvular involvement (p = 0.02). aPL may play a role in the pathogenesis of some clinical manifestations of acute rheumatic fever.

Original languageEnglish
Pages (from-to)1175-1180
Number of pages6
JournalJournal of Rheumatology
Issue number8
StatePublished - 1992


  • Sydenham chorea
  • antiphospholipid/anticardiolipin antibodies
  • rheumatic fever
  • rheumatic heart disease


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