An update on parathyroid carcinoma: Carcinoma paratiroideo

MARCELA BARBERÁN, CLAUDIA CAMPUSANO, PATRICIO SALMAN, PAMELA TREJO, ANGÉLICA SILVA-FIGUEROA, SANDRA RIVERA, PABLO FLORENZANO, SOLEDAD VELASCO, FRANCISCA ILLANES, PATRICIO TRINCADO, JOSÉ CANESSA, ANTONIETA SOLAR, MARCELA MORENO, DANIELA EUGENIN, BEATRIZ JIMÉNEZ, PATRICIA ARROYO

Research output: Contribution to journalArticlepeer-review

Abstract

Parathyroid carcinoma is a rare malignant disease that presents as a sporadic or familial primary hyperparathyroidism (PHP). The latter is associated with some genetic syndromes. It occurs with equal frequency in both sexes, unlike PHP caused by parathyroid adenoma that is more common in women. It should be suspected in cases of severe hypercalcemia, with high parathyroid hormone levels and a palpable cervical mass. Given the difficulty in distinguishing between parathyroid carcinoma and adenoma prior to the surgery, the diagnosis is often made after parathyroidectomy. The only curative treatment is complete surgical resection with oncologic block resection of the primary tumor to ensure free margins. Adjuvant therapies with chemotherapy or radiation therapy do not modify overall or disease-free survival. Recurrences are common and re-operation of resectable recurrent disease is recommended. The palliative treatment of symptomatic hypercalcemia is crucial in persistent or recurrent disease after surgery since morbidity and mortality are more associated with hypercalcemia than with tumor burden.

Translated title of the contributionAn update on parathyroid carcinoma
Original languageSpanish
Pages (from-to)399-408
Number of pages10
JournalRevista Medica de Chile
Volume149
Issue number3
DOIs
StatePublished - Mar 2021

Bibliographical note

Publisher Copyright:
© 2021 Sociedad Medica de Santiago. All rights reserved.

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