Amniotic fluid concentrations of prostaglandin F, 13,14-dihyro-15-keto-prostaglandin F (PGFM) and 11-deoxy-13,14-dihydro-15-keto-11, 16-cyclo-prostaglandin E2 (PGEM-LL) in preterm labor.

R. Romero*, Y. King Wu, M. Sirtori, E. Oyarzun, M. Mazor, J. C. Hobbins, M. D. Mitchell

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

52 Scopus citations

Abstract

Although prostaglandins (PGs) are considered the key mediators of human parturition at term, there is a paucity of data regarding their participation in the mechanisms responsible for preterm labor. The purpose of this study was to establish if preterm labor is associated with changes in the amniotic fluid concentrations of prostaglandins. PGF, 13,14-dihydro-15-keto-prostaglandin F (PGFM) and 11-deoxy-13,14-dihydro-15-keto-11,16-cyclo-prostaglandin E2 (PGEM-II) were measured by using specific and sensitive radioimmunoassays. Amniotic fluid was retrieved by transabdominal amniocentesis from 55 women with preterm labor and intact membranes. Patients were divided into three groups according to the response to tocolysis and the presence or absence of an intra-amniotic infection. Amniotic fluid concentrations of PGFM and PGEM-II were significantly greater in women with preterm labor and intra-amniotic infection than in women without infection. In addition, patients unresponsive to tocolysis without intra-amniotic infection also had a significantly greater concentration of PGFM and PGEM-II in amniotic fluid than those responsive to tocolysis. Amniotic fluid concentrations of PGF were greater in women with intra-amniotic infection than in women without intra-amniotic infection. In the absence of intra-amniotic infection, no difference in amniotic fluid PGF concentrations could be found between women who responded to tocolytic treatment and those who did not.

Original languageEnglish
Pages (from-to)149-161
Number of pages13
JournalProstaglandins
Volume37
Issue number1
DOIs
StatePublished - Jan 1989
Externally publishedYes

Bibliographical note

Funding Information:
Supported by grants from the Walter Scott Foundation for Medical Research and NIH Grant HD 20779. Dr. Romero is the recipient of a Physician Scientist Award from the National Institutes of Child Health and Human Development. We would like to acknowledge the support and advice of Dr. Harold Behrman.

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