Abstract
For nano-scale surface modification and biofabrication purposes, it is necessary to first understand the variations in adsorption behavior of certain carbopolymers. Assembled polyelectrolyte multi-layers (PEMs) composed of two naturally-derived polyelectrolytes; chitosan (CHI) and alginate (ALG) were alternatively deposited via the layer-by-layer technique-in reversed order-on planar gold (Au) surfaces and monitored in situ by means of quartz crystal microbalance with dissipation (QCM-D) in real-time. QCM-D revealed that [ALG-CHI]10 flilms were compact yet soft with thickness in the range of 240 nm compared to a more open [CHI-ALG]10 system with 91 nm. Such differences in visco-elastic properties of PEMs were the result of different growth regimes employed. To the best of our knowledge, this is the first QCM-D demonstration of the difference in multi-layer structure by alternate assembly of ALG and CHI on a flat surface. Findings suggest that more robust PEMs could be produced when ALG is the prime base layer.
| Original language | American English |
|---|---|
| Pages (from-to) | 83-88 |
| Number of pages | 6 |
| Journal | Journal of Biomaterials and Tissue Engineering |
| Volume | 2 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1 Mar 2012 |
| Externally published | Yes |
Keywords
- Alginate
- Chitosan
- Film
- Layer-by-layer
- Polyelectrolytes
- Thickness
- Visco-elastic