TY - JOUR
T1 - Aging and putative frailty biomarkers are altered by spaceflight
AU - Camera, Andrea
AU - Tabetah, Marshall
AU - Castañeda, Veronica
AU - Kim, Jang Keun
AU - Galsinh, Aman Singh
AU - Haro-Vinueza, Alissen
AU - Salinas, Ivonne
AU - Seylani, Allen
AU - Arif, Shehbeel
AU - Das, Saswati
AU - Mori, Marcelo A.
AU - Carano, Anthony
AU - de Oliveira, Lorraine Christine
AU - Muratani, Masafumi
AU - Barker, Richard
AU - Zaksas, Victoria
AU - Goel, Chirag
AU - Dimokidis, Eleni
AU - Taylor, Deanne M.
AU - Jeong, Jisu
AU - Overbey, Eliah
AU - Meydan, Cem
AU - Porterfield, D. Marshall
AU - Díaz, Juan Esteban
AU - Caicedo, Andrés
AU - Schisler, Jonathan C.
AU - Laiakis, Evagelia C.
AU - Mason, Christopher E.
AU - Kim, Man S.
AU - Karouia, Fathi
AU - Szewczyk, Nathaniel J.
AU - Beheshti, Afshin
N1 - Publisher Copyright:
© The Author(s) 2024.
PY - 2024/12
Y1 - 2024/12
N2 - Human space exploration poses inherent risks to astronauts’ health, leading to molecular changes that can significantly impact their well-being. These alterations encompass genomic instability, mitochondrial dysfunction, increased inflammation, homeostatic dysregulation, and various epigenomic changes. Remarkably, these changes bear similarities to those observed during the aging process on Earth. However, our understanding of the connection between these molecular shifts and disease development in space remains limited. Frailty syndrome, a clinical syndrome associated with biological aging, has not been comprehensively investigated during spaceflight. To bridge this knowledge gap, we leveraged murine data obtained from NASA’s GeneLab, along with astronaut data gathered from the JAXA and Inspiration4 missions. Our objective was to assess the presence of biological markers and pathways related to frailty, aging, and sarcopenia within the spaceflight context. Through our analysis, we identified notable changes in gene expression patterns that may be indicative of the development of a frailty-like condition during space missions. These findings suggest that the parallels between spaceflight and the aging process may extend to encompass frailty as well. Consequently, further investigations exploring the utility of a frailty index in monitoring astronaut health appear to be warranted.
AB - Human space exploration poses inherent risks to astronauts’ health, leading to molecular changes that can significantly impact their well-being. These alterations encompass genomic instability, mitochondrial dysfunction, increased inflammation, homeostatic dysregulation, and various epigenomic changes. Remarkably, these changes bear similarities to those observed during the aging process on Earth. However, our understanding of the connection between these molecular shifts and disease development in space remains limited. Frailty syndrome, a clinical syndrome associated with biological aging, has not been comprehensively investigated during spaceflight. To bridge this knowledge gap, we leveraged murine data obtained from NASA’s GeneLab, along with astronaut data gathered from the JAXA and Inspiration4 missions. Our objective was to assess the presence of biological markers and pathways related to frailty, aging, and sarcopenia within the spaceflight context. Through our analysis, we identified notable changes in gene expression patterns that may be indicative of the development of a frailty-like condition during space missions. These findings suggest that the parallels between spaceflight and the aging process may extend to encompass frailty as well. Consequently, further investigations exploring the utility of a frailty index in monitoring astronaut health appear to be warranted.
UR - http://www.scopus.com/inward/record.url?scp=85195888380&partnerID=8YFLogxK
U2 - 10.1038/s41598-024-57948-5
DO - 10.1038/s41598-024-57948-5
M3 - Article
C2 - 38862573
AN - SCOPUS:85195888380
SN - 2045-2322
VL - 14
JO - Scientific Reports
JF - Scientific Reports
IS - 1
M1 - 13098
ER -
