Adherens junctions and cell polarity: what they are and how they relate to congenital Zika virus syndrome

Felipe A. Bustamante-Barrientos, Roberto Henzi, Luis Federico Bátiz

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Adherens junctions (AJs) comprise cell-cell adhesion complexes that are organized as belt-like structures at the most apical-lateral plasma membrane. In embryonic neural stem and progenitor cells (NSPCs), these junctional complexes are essential for the maintenance of the ventricular lining and the cerebral cytoarchitecture. Several reports in humans and animal models have shown that loss of function of proteins involved in the assembly and/or turnover of AJ components gives rise to a phenotype characterized by disruption of the ventricular zone, increased cell death, and defective corticogenesis. In turn, these models consistently replicate a wide range of defects expressed by vertical transmission of Zika virus (ZIKV), a flavivirus with a high tropism by neural tissues. This chapter summarizes relevant aspects of the structure and function of AJs during brain development and provides novel insights that may contribute to the current knowledge about the etiopathogenesis of congenital ZIKV syndrome (CZS).

Original languageEnglish
Title of host publicationZika Virus Impact, Diagnosis, Control, and Models
Subtitle of host publicationVolume 2: The Neuroscience of Zika Virus
EditorsColin R. Martin, Caroline J. Hollins Martin, Victor R. Preedy, Rajkumar Rajendram
Place of PublicationEstados Unidos
Number of pages12
ISBN (Electronic)9780128202678
ISBN (Print)978-0-12-820267-8
StatePublished - 2021

Publication series

NameZika Virus Impact, Diagnosis, Control, and Models

Bibliographical note

Publisher Copyright:
© 2021 Elsevier Inc. All rights reserved.


  • Brain cortex
  • Cell-cell adhesion
  • Flaviviruses
  • Microcephaly
  • N-Cadherin
  • Neural stem cells
  • Neurodevelopmental defects
  • Neurogenesis
  • Zika virus


Dive into the research topics of 'Adherens junctions and cell polarity: what they are and how they relate to congenital Zika virus syndrome'. Together they form a unique fingerprint.

Cite this