Acquired oral syphilis: A multicenter study of 339 patients from South America

Bruno Augusto Benevenuto de Andrade; José Alcides Almeida de Arruda; Gerardo Gilligan; Eduardo Piemonte; René Panico; Ignacio Molina Ávila; Juan Martin Pimentel Sola; Martha Cecilia Carmona Lorduy; Stella Pupo Marrugo; Angélica Sofia Sánchez Tatis; Laura Cecilia Werner; Aline Corrêa Abrahão; Michelle Agostini; Luisa Buoro; Mônica Simões Israel; Nathália de Almeida Freire; Lucas Ambrósio Lima; Thamiris de Castro Abrantes; John Lennon Silva Cunha; Maria Eduarda Pérez-de-Oliveira; Ana Luiza Oliveira Corrêa Roza; Pablo Agustin Vargas; Marcio Ajudarte Lopes; Alan Roger Santos-Silva; Oslei Paes de Almeida; Flávia Sirotheau Corrêa Pontes; Hélder Antônio Rebelo Pontes; Benjamin Martínez Rondanelli; Mariana Villarroel-Dorrego; Ronell Bologna-Molina; Nathalie Derderian; Celeste Sánchez-Romero; Lucas Guimarães Abreu; Felipe Paiva Fonseca; Ricardo Alves Mesquita; Ricardo Santiago Gomez; René Martínez-Flores; Wilson Delgado-Azañero; Adriana Terezinha Neves Novellino Alves; Simone de Queiroz Chaves Lourenço; Carolina Coimbra; Giovanni Augusto Castanheira Polignano; José Narciso Rosa Assunção Júnior; Giovanna Ribeiro Souto; Paulo Eduardo Alencar Souza; Martinho Campolina Rebello Horta; Wilfredo Alejandro González-Arriagada; Mário José Romañach

doi:10.1111/odi.13963

Acquired oral syphilis: A multicenter study of 339 patients from South America

Bruno Augusto Benevenuto de Andrade^*, José Alcides Almeida de Arruda, Gerardo Gilligan, Eduardo Piemonte, René Panico, Ignacio Molina Ávila, Juan Martin Pimentel Sola, Martha Cecilia Carmona Lorduy, Stella Pupo Marrugo, Angélica Sofia Sánchez Tatis, Laura Cecilia Werner, Aline Corrêa Abrahão, Michelle Agostini, Luisa Buoro, Mônica Simões Israel, Nathália de Almeida Freire, Lucas Ambrósio Lima, Thamiris de Castro Abrantes, John Lennon Silva Cunha, Maria Eduarda Pérez-de-OliveiraAna Luiza Oliveira Corrêa Roza, Pablo Agustin Vargas, Marcio Ajudarte Lopes, Alan Roger Santos-Silva, Oslei Paes de Almeida, Flávia Sirotheau Corrêa Pontes, Hélder Antônio Rebelo Pontes, Benjamin Martínez Rondanelli, Mariana Villarroel-Dorrego, Ronell Bologna-Molina, Nathalie Derderian, Celeste Sánchez-Romero, Lucas Guimarães Abreu, Felipe Paiva Fonseca, Ricardo Alves Mesquita, Ricardo Santiago Gomez, René Martínez-Flores, Wilson Delgado-Azañero, Adriana Terezinha Neves Novellino Alves, Simone de Queiroz Chaves Lourenço, Carolina Coimbra, Giovanni Augusto Castanheira Polignano, José Narciso Rosa Assunção Júnior, Giovanna Ribeiro Souto, Paulo Eduardo Alencar Souza, Martinho Campolina Rebello Horta, Wilfredo Alejandro González-Arriagada, Mário José Romañach

^*Corresponding author for this work

Facultad de Odontología

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Objective: To report the clinicopathologic features of acquired oral syphilis cases in South American countries. Materials and Methods: Clinical data were retrospectively collected from the records of 18 oral diagnostic services in Argentina, Brazil, Chile, Colombia, Venezuela, Uruguay, and Peru. Serologies of nontreponemal and treponemal tests were used for diagnosis. Results: The series comprised 339 cases of acquired oral syphilis. Secondary syphilis ranked as the most common stage (86.7%). Lesions were more frequent among males (58.0%) and young adults with a mean age of 33.3 years. Individuals aged 20–29 years were most affected (35.3%). The most commonly involved sites were the tongue (31.6%), lip/labial commissure (25.1%), and hard/soft palate (20.4%). Clinically, acquired oral syphilis usually presented as mucous patches (28.4%), papules (25.7%), and ulcers (18.1%). Skin manifestations occurred in 67.7% of individuals, while lymphadenopathy and fever were observed in 61.3% and 11.6% of all subjects, respectively. Most patients were treated with the benzathine penicillin G antibiotic. Conclusion: This report validates the spread of acquired oral syphilis infection among young adults in South America. Our directives include accessible diagnostic tools for proper disease screening, surveillance, and counselling of affected individuals, especially in low- and middle-income countries.

Original language	English
Pages (from-to)	1561-1572
Number of pages	12
Journal	Oral Diseases
Volume	28
Issue number	6
Early online date	15 Jul 2021
DOIs	https://doi.org/10.1111/odi.13963
State	Published - Aug 2021

Bibliographical note

Funding Information:
This study was supported by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES, Finance Code 001), Brazil. We thank Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Brazil. Mrs. E. Greene provided English editing of the manuscript.

Publisher Copyright:
© 2021 Wiley Periodicals LLC

Keywords

acquired syphilis
oral mucosa
public health
sexually transmitted infections
syphilis
Treponema pallidum

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/odi.13963

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de Andrade, B. A. B., de Arruda, J. A. A., Gilligan, G., Piemonte, E., Panico, R., Molina Ávila, I., Pimentel Sola, J. M., Carmona Lorduy, M. C., Pupo Marrugo, S., Sánchez Tatis, A. S., Werner, L. C., Abrahão, A. C., Agostini, M., Buoro, L., Israel, M. S., Freire, N. D. A., Lima, L. A., Abrantes, T. D. C., Cunha, J. L. S., ... Romañach, M. J. (2021). Acquired oral syphilis: A multicenter study of 339 patients from South America. Oral Diseases, 28(6), 1561-1572. https://doi.org/10.1111/odi.13963

@article{3ba11d14f03a4906b69f82556ecad2cd,

title = "Acquired oral syphilis: A multicenter study of 339 patients from South America",

abstract = "Objective: To report the clinicopathologic features of acquired oral syphilis cases in South American countries. Materials and Methods: Clinical data were retrospectively collected from the records of 18 oral diagnostic services in Argentina, Brazil, Chile, Colombia, Venezuela, Uruguay, and Peru. Serologies of nontreponemal and treponemal tests were used for diagnosis. Results: The series comprised 339 cases of acquired oral syphilis. Secondary syphilis ranked as the most common stage (86.7%). Lesions were more frequent among males (58.0%) and young adults with a mean age of 33.3 years. Individuals aged 20–29 years were most affected (35.3%). The most commonly involved sites were the tongue (31.6%), lip/labial commissure (25.1%), and hard/soft palate (20.4%). Clinically, acquired oral syphilis usually presented as mucous patches (28.4%), papules (25.7%), and ulcers (18.1%). Skin manifestations occurred in 67.7% of individuals, while lymphadenopathy and fever were observed in 61.3% and 11.6% of all subjects, respectively. Most patients were treated with the benzathine penicillin G antibiotic. Conclusion: This report validates the spread of acquired oral syphilis infection among young adults in South America. Our directives include accessible diagnostic tools for proper disease screening, surveillance, and counselling of affected individuals, especially in low- and middle-income countries.",

keywords = "acquired syphilis, oral mucosa, public health, sexually transmitted infections, syphilis, Treponema pallidum, Treponema pallidum, Acquired syphilis, Oral mucosa, Public health, Sexually transmitted infections, Syphilis",

author = "{de Andrade}, {Bruno Augusto Benevenuto} and {de Arruda}, {Jos{\'e} Alcides Almeida} and Gerardo Gilligan and Eduardo Piemonte and Ren{\'e} Panico and {Molina {\'A}vila}, Ignacio and {Pimentel Sola}, {Juan Martin} and {Carmona Lorduy}, {Martha Cecilia} and {Pupo Marrugo}, Stella and {S{\'a}nchez Tatis}, {Ang{\'e}lica Sofia} and Werner, {Laura Cecilia} and Abrah{\~a}o, {Aline Corr{\^e}a} and Michelle Agostini and Luisa Buoro and Israel, {M{\^o}nica Sim{\~o}es} and Freire, {Nath{\'a}lia de Almeida} and Lima, {Lucas Ambr{\'o}sio} and Abrantes, {Thamiris de Castro} and Cunha, {John Lennon Silva} and P{\'e}rez-de-Oliveira, {Maria Eduarda} and Roza, {Ana Luiza Oliveira Corr{\^e}a} and Vargas, {Pablo Agustin} and Lopes, {Marcio Ajudarte} and Santos-Silva, {Alan Roger} and {de Almeida}, {Oslei Paes} and Pontes, {Fl{\'a}via Sirotheau Corr{\^e}a} and Pontes, {H{\'e}lder Ant{\^o}nio Rebelo} and Rondanelli, {Benjamin Mart{\'i}nez} and Mariana Villarroel-Dorrego and Ronell Bologna-Molina and Nathalie Derderian and Celeste S{\'a}nchez-Romero and Abreu, {Lucas Guimar{\~a}es} and Fonseca, {Felipe Paiva} and Mesquita, {Ricardo Alves} and Gomez, {Ricardo Santiago} and Ren{\'e} Mart{\'i}nez-Flores and Wilson Delgado-Aza{\~n}ero and Alves, {Adriana Terezinha Neves Novellino} and Louren{\c c}o, {Simone de Queiroz Chaves} and Carolina Coimbra and Polignano, {Giovanni Augusto Castanheira} and {Assun{\c c}{\~a}o J{\'u}nior}, {Jos{\'e} Narciso Rosa} and Souto, {Giovanna Ribeiro} and Souza, {Paulo Eduardo Alencar} and Horta, {Martinho Campolina Rebello} and Gonz{\'a}lez-Arriagada, {Wilfredo Alejandro} and Roma{\~n}ach, {M{\'a}rio Jos{\'e}}",

note = "Funding Information: This study was supported by Coordena{\c c}{\~a}o de Aperfei{\c c}oamento de Pessoal de N{\'i}vel Superior (CAPES, Finance Code 001), Brazil. We thank Conselho Nacional de Desenvolvimento Cient{\'i}fico e Tecnol{\'o}gico (CNPq), Brazil. Mrs. E. Greene provided English editing of the manuscript. Publisher Copyright: {\textcopyright} 2021 Wiley Periodicals LLC",

year = "2021",

month = aug,

doi = "10.1111/odi.13963",

language = "English",

volume = "28",

pages = "1561--1572",

journal = "Oral Diseases",

issn = "1354-523X",

publisher = "Wiley-Blackwell",

number = "6",

}

de Andrade, BAB, de Arruda, JAA, Gilligan, G, Piemonte, E, Panico, R, Molina Ávila, I, Pimentel Sola, JM, Carmona Lorduy, MC, Pupo Marrugo, S, Sánchez Tatis, AS, Werner, LC, Abrahão, AC, Agostini, M, Buoro, L, Israel, MS, Freire, NDA, Lima, LA, Abrantes, TDC, Cunha, JLS, Pérez-de-Oliveira, ME, Roza, ALOC, Vargas, PA, Lopes, MA, Santos-Silva, AR, de Almeida, OP, Pontes, FSC, Pontes, HAR, Rondanelli, BM, Villarroel-Dorrego, M, Bologna-Molina, R, Derderian, N, Sánchez-Romero, C, Abreu, LG, Fonseca, FP, Mesquita, RA, Gomez, RS, Martínez-Flores, R, Delgado-Azañero, W, Alves, ATNN, Lourenço, SDQC, Coimbra, C, Polignano, GAC, Assunção Júnior, JNR, Souto, GR, Souza, PEA, Horta, MCR, González-Arriagada, WA & Romañach, MJ 2021, 'Acquired oral syphilis: A multicenter study of 339 patients from South America', Oral Diseases, vol. 28, no. 6, pp. 1561-1572. https://doi.org/10.1111/odi.13963

TY - JOUR

T1 - Acquired oral syphilis

T2 - A multicenter study of 339 patients from South America

AU - de Andrade, Bruno Augusto Benevenuto

AU - de Arruda, José Alcides Almeida

AU - Gilligan, Gerardo

AU - Piemonte, Eduardo

AU - Panico, René

AU - Molina Ávila, Ignacio

AU - Pimentel Sola, Juan Martin

AU - Carmona Lorduy, Martha Cecilia

AU - Pupo Marrugo, Stella

AU - Sánchez Tatis, Angélica Sofia

AU - Werner, Laura Cecilia

AU - Abrahão, Aline Corrêa

AU - Agostini, Michelle

AU - Buoro, Luisa

AU - Israel, Mônica Simões

AU - Freire, Nathália de Almeida

AU - Lima, Lucas Ambrósio

AU - Abrantes, Thamiris de Castro

AU - Cunha, John Lennon Silva

AU - Pérez-de-Oliveira, Maria Eduarda

AU - Roza, Ana Luiza Oliveira Corrêa

AU - Vargas, Pablo Agustin

AU - Lopes, Marcio Ajudarte

AU - Santos-Silva, Alan Roger

AU - de Almeida, Oslei Paes

AU - Pontes, Flávia Sirotheau Corrêa

AU - Pontes, Hélder Antônio Rebelo

AU - Rondanelli, Benjamin Martínez

AU - Villarroel-Dorrego, Mariana

AU - Bologna-Molina, Ronell

AU - Derderian, Nathalie

AU - Sánchez-Romero, Celeste

AU - Abreu, Lucas Guimarães

AU - Fonseca, Felipe Paiva

AU - Mesquita, Ricardo Alves

AU - Gomez, Ricardo Santiago

AU - Martínez-Flores, René

AU - Delgado-Azañero, Wilson

AU - Alves, Adriana Terezinha Neves Novellino

AU - Lourenço, Simone de Queiroz Chaves

AU - Coimbra, Carolina

AU - Polignano, Giovanni Augusto Castanheira

AU - Assunção Júnior, José Narciso Rosa

AU - Souto, Giovanna Ribeiro

AU - Souza, Paulo Eduardo Alencar

AU - Horta, Martinho Campolina Rebello

AU - González-Arriagada, Wilfredo Alejandro

AU - Romañach, Mário José

N1 - Funding Information: This study was supported by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES, Finance Code 001), Brazil. We thank Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Brazil. Mrs. E. Greene provided English editing of the manuscript. Publisher Copyright: © 2021 Wiley Periodicals LLC

PY - 2021/8

Y1 - 2021/8

N2 - Objective: To report the clinicopathologic features of acquired oral syphilis cases in South American countries. Materials and Methods: Clinical data were retrospectively collected from the records of 18 oral diagnostic services in Argentina, Brazil, Chile, Colombia, Venezuela, Uruguay, and Peru. Serologies of nontreponemal and treponemal tests were used for diagnosis. Results: The series comprised 339 cases of acquired oral syphilis. Secondary syphilis ranked as the most common stage (86.7%). Lesions were more frequent among males (58.0%) and young adults with a mean age of 33.3 years. Individuals aged 20–29 years were most affected (35.3%). The most commonly involved sites were the tongue (31.6%), lip/labial commissure (25.1%), and hard/soft palate (20.4%). Clinically, acquired oral syphilis usually presented as mucous patches (28.4%), papules (25.7%), and ulcers (18.1%). Skin manifestations occurred in 67.7% of individuals, while lymphadenopathy and fever were observed in 61.3% and 11.6% of all subjects, respectively. Most patients were treated with the benzathine penicillin G antibiotic. Conclusion: This report validates the spread of acquired oral syphilis infection among young adults in South America. Our directives include accessible diagnostic tools for proper disease screening, surveillance, and counselling of affected individuals, especially in low- and middle-income countries.

AB - Objective: To report the clinicopathologic features of acquired oral syphilis cases in South American countries. Materials and Methods: Clinical data were retrospectively collected from the records of 18 oral diagnostic services in Argentina, Brazil, Chile, Colombia, Venezuela, Uruguay, and Peru. Serologies of nontreponemal and treponemal tests were used for diagnosis. Results: The series comprised 339 cases of acquired oral syphilis. Secondary syphilis ranked as the most common stage (86.7%). Lesions were more frequent among males (58.0%) and young adults with a mean age of 33.3 years. Individuals aged 20–29 years were most affected (35.3%). The most commonly involved sites were the tongue (31.6%), lip/labial commissure (25.1%), and hard/soft palate (20.4%). Clinically, acquired oral syphilis usually presented as mucous patches (28.4%), papules (25.7%), and ulcers (18.1%). Skin manifestations occurred in 67.7% of individuals, while lymphadenopathy and fever were observed in 61.3% and 11.6% of all subjects, respectively. Most patients were treated with the benzathine penicillin G antibiotic. Conclusion: This report validates the spread of acquired oral syphilis infection among young adults in South America. Our directives include accessible diagnostic tools for proper disease screening, surveillance, and counselling of affected individuals, especially in low- and middle-income countries.

KW - acquired syphilis

KW - oral mucosa

KW - public health

KW - sexually transmitted infections

KW - syphilis

KW - Treponema pallidum

KW - Acquired syphilis

KW - Oral mucosa

KW - Public health

KW - Sexually transmitted infections

KW - Syphilis

UR - http://www.scopus.com/inward/record.url?scp=85127229686&partnerID=8YFLogxK

U2 - 10.1111/odi.13963

DO - 10.1111/odi.13963

M3 - Article

C2 - 34263964

SN - 1354-523X

VL - 28

SP - 1561

EP - 1572

JO - Oral Diseases

JF - Oral Diseases

IS - 6

ER -

Acquired oral syphilis: A multicenter study of 339 patients from South America

Abstract

Bibliographical note

Keywords

UN SDGs

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