A retinoic acid-dependent checkpoint in the development of CD4+ T cell-mediated immunity

Karina Pino-Lagos, Yanxia Guo, Chrysothemis Brown, Matthew P. Alexander, Raúl Elgueta, Kathryn A. Bennett, Victor De Vries, Elizabeth Nowak, Rune Blomhoff, Shanthini Sockanathan, Roshantha A. Chandraratna, Ethan Dmitrovsky, Randolph J. Noelle*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

104 Scopus citations


It is known that vitamin A and its metabolite, retinoic acid (RA), are essential for host defense. However, the mechanisms for how RA controls inflammation are incompletely understood. The findings presented in this study show that RA signaling occurs concurrent with the development of inflammation. In models of vaccination and allogeneic graft rejection, whole body imaging reveals that RA signaling is temporally and spatially restricted to the site of inflammation. Conditional ablation of RA signaling in T cells significantly interferes with CD4+ T cell effector function, migration, and polarity. These findings provide a new perspective of the role of RA as a mediator directly controlling CD4+ T cell differentiation and immunity.

Original languageEnglish
Pages (from-to)1767-1775
Number of pages9
JournalJournal of Experimental Medicine
Issue number9
StatePublished - 29 Aug 2011
Externally publishedYes


  • Dendritic cells
  • Vitamin-a
  • Small-intestine
  • Receptor-alpha
  • Expressio
  • Differentiation
  • Generation
  • Induction
  • System


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