A retinoic acid-dependent checkpoint in the development of CD4+ T cell-mediated immunity

Karina Pino-Lagos; Yanxia Guo; Chrysothemis Brown; Matthew P. Alexander; Raúl Elgueta; Kathryn A. Bennett; Victor De Vries; Elizabeth Nowak; Rune Blomhoff; Shanthini Sockanathan; Roshantha A. Chandraratna; Ethan Dmitrovsky; Randolph J. Noelle

doi:10.1084/jem.20102358

A retinoic acid-dependent checkpoint in the development of CD4⁺ T cell-mediated immunity

Karina Pino-Lagos, Yanxia Guo, Chrysothemis Brown, Matthew P. Alexander, Raúl Elgueta, Kathryn A. Bennett, Victor De Vries, Elizabeth Nowak, Rune Blomhoff, Shanthini Sockanathan, Roshantha A. Chandraratna, Ethan Dmitrovsky, Randolph J. Noelle^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

104 Scopus citations

Abstract

It is known that vitamin A and its metabolite, retinoic acid (RA), are essential for host defense. However, the mechanisms for how RA controls inflammation are incompletely understood. The findings presented in this study show that RA signaling occurs concurrent with the development of inflammation. In models of vaccination and allogeneic graft rejection, whole body imaging reveals that RA signaling is temporally and spatially restricted to the site of inflammation. Conditional ablation of RA signaling in T cells significantly interferes with CD4⁺ T cell effector function, migration, and polarity. These findings provide a new perspective of the role of RA as a mediator directly controlling CD4⁺ T cell differentiation and immunity.

Original language	English
Pages (from-to)	1767-1775
Number of pages	9
Journal	Journal of Experimental Medicine
Volume	208
Issue number	9
DOIs	https://doi.org/10.1084/jem.20102358
State	Published - 29 Aug 2011
Externally published	Yes

Keywords

Dendritic cells
Vitamin-a
Small-intestine
Receptor-alpha
Expressio
Differentiation
Generation
Induction
System

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1084/jem.20102358

Cite this

Pino-Lagos, K., Guo, Y., Brown, C., Alexander, M. P., Elgueta, R., Bennett, K. A., De Vries, V., Nowak, E., Blomhoff, R., Sockanathan, S., Chandraratna, R. A., Dmitrovsky, E., & Noelle, R. J. (2011). A retinoic acid-dependent checkpoint in the development of CD4⁺ T cell-mediated immunity. Journal of Experimental Medicine, 208(9), 1767-1775. https://doi.org/10.1084/jem.20102358

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abstract = "It is known that vitamin A and its metabolite, retinoic acid (RA), are essential for host defense. However, the mechanisms for how RA controls inflammation are incompletely understood. The findings presented in this study show that RA signaling occurs concurrent with the development of inflammation. In models of vaccination and allogeneic graft rejection, whole body imaging reveals that RA signaling is temporally and spatially restricted to the site of inflammation. Conditional ablation of RA signaling in T cells significantly interferes with CD4+ T cell effector function, migration, and polarity. These findings provide a new perspective of the role of RA as a mediator directly controlling CD4+ T cell differentiation and immunity.",

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Pino-Lagos, K, Guo, Y, Brown, C, Alexander, MP, Elgueta, R, Bennett, KA, De Vries, V, Nowak, E, Blomhoff, R, Sockanathan, S, Chandraratna, RA, Dmitrovsky, E & Noelle, RJ 2011, 'A retinoic acid-dependent checkpoint in the development of CD4⁺ T cell-mediated immunity', Journal of Experimental Medicine, vol. 208, no. 9, pp. 1767-1775. https://doi.org/10.1084/jem.20102358

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AU - Guo, Yanxia

AU - Brown, Chrysothemis

AU - Alexander, Matthew P.

AU - Elgueta, Raúl

AU - Bennett, Kathryn A.

AU - De Vries, Victor

AU - Nowak, Elizabeth

AU - Blomhoff, Rune

AU - Sockanathan, Shanthini

AU - Chandraratna, Roshantha A.

AU - Dmitrovsky, Ethan

AU - Noelle, Randolph J.

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