A report on the International Society for Cell & Gene Therapy 2022 Scientific Signature Series, “Therapeutic advances with native and engineered human extracellular vesicles”

Wei Seong Toh, Reza Yarani, Samir El Andaloussi, Byong Seung Cho, Chulhee Choi, Randolph Corteling, Antonin De Fougerolles, Mario Gimona, Josephine Herz, Maroun Khoury, Paul D. Robbins, Douglas Williams, Daniel J. Weiss, Eva Rohde, Bernd Giebel*, Sai Kiang Lim*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

The International Society for Cell & Gene Therapy Scientific Signature Series event “Therapeutic Advances With Native and Engineered Human EVs” took place as part of the International Society for Cell & Gene Therapy 2022 Annual Meeting, held from May 4 to 7, 2022, in San Francisco, California, USA. This was the first signature series event on extracellular vesicles (EVs) and a timely reflection of the growing interest in EVs, including both native and engineered human EVs, for therapeutic applications. The event successfully gathered academic and industrial key opinion leaders to discuss the current state of the art in developing and understanding native and engineered EVs and applying our knowledge toward advancing EV therapeutics. Latest advancements in understanding the mechanisms by which native and engineered EVs exert their therapeutic effects against different diseases in animal models were presented, with some diseases such as psoriasis and osteoarthritis already reaching clinical testing of EVs. The discussion also covered various aspects relevant to advancing the clinical translation of EV therapies, including EV preparation, manufacturing, consistency, site(s) of action, route(s) of administration, and luminal cargo delivery of RNA and other compounds.

Original languageEnglish
Pages (from-to)810-814
Number of pages5
JournalCytotherapy
Volume25
Issue number8
DOIs
StatePublished - Aug 2023
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2023 International Society for Cell & Gene Therapy

Keywords

  • clinical trials
  • exosomes
  • extracellular vesicles
  • mesenchymal stromal cells
  • therapeutic
  • translation

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