A randomized trial of pharmacotherapy with telephone monitoring to improve treatment of depression in primary care in Santiago, Chile

Rosemarie Fritsch, Ricardo Araya, Jaime Solís, Elena Montt, Daniel Pilowsky, Graciela Rojas

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Background: Depression is a public health problem, due to its high prevalence and its associated disability. Aim: To compare a pharmacological intervention for depression controlled by phone from a central level (TM) and the usual treatment (TH) in a randomized clinical trial. Material and methods: Three hundred and forty five women, aged 22 to 59 years were studied. They were randomly assigned to receive the usual therapy or a pharmacological intervention with periodical telephone contacts with medical collaboration personnel, to reinforce compliance with treatment and educate about the disease. Women were blindly evaluated at 3 and 6 months with the Hamilton depression rating score (HDRS) and the SF-36 to assess depressive symptoms and quality of life, respectively. Results: In both evaluations, improvement was significantly greater in the TM group than the TH group. At 3 months, improvement was higher in the TM group in the subscales of physical function, pain, general health, energy, emotional role, mental health and standardized physical and psychic scales of SF-36. At 6 months, this significant difference in favour of TM was maintained for energy, mental health and the standardized psychic scale. Conclusions: A telephone reinforcement improves the outcomes of treatments for depression.

Translated title of the contributionA randomized trial of pharmacotherapy with telephone monitoring to improve treatment of depression in primary care in Santiago, Chile
Original languageSpanish
Pages (from-to)587-595
Number of pages9
JournalRevista Medica de Chile
Volume135
Issue number5
StatePublished - May 2007
Externally publishedYes

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