A Precision Medicine Guided Approach to the Utilization of Biomarkers in MASLD

Nimish Thakral, Hailemichael Desalegn, Luis Antonio Diaz, Daniel Cabrera, Rohit Loomba, Marco Arrese, Juan Pablo Arab*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The new nomenclature of metabolic dysfunction-associated steatotic liver disease (MASLD) emphasizes a positive diagnosis based on cardiometabolic risk factors. This definition is not only less stigmatizing but also allows for subclassification and stratification, thereby addressing the heterogeneity of what was historically referred to as nonalcoholic fatty liver disease. The heterogeneity within this spectrum is influenced by several factors which include but are not limited to demographic/dietary factors, the amount of alcohol use and drinking patterns, metabolic status, gut microbiome, genetic predisposition together with epigenetic factors. The net effect of this dynamic and intricate system-level interaction is reflected in the phenotypic presentation of MASLD. Therefore, the application of precision medicine in this scenario aims at complex phenotyping with consequent individual risk prediction, development of individualized preventive strategies, and improvements in the clinical trial designs. In this review, we aim to highlight the importance of precision medicine approaches in MASLD, including the use of novel biomarkers of disease, and its subsequent utilization in future study designs.

Original languageEnglish
Pages (from-to)273-286
Number of pages14
JournalSeminars in Liver Disease
Volume44
Issue number3
DOIs
StatePublished - 26 Jul 2024

Bibliographical note

Publisher Copyright:
© 2024 Thieme Medical Publishers, Inc.. All rights reserved.

Keywords

  • MASLD
  • biomarkers
  • cirrhosis
  • precision medicine
  • steatosis

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