A potential role for epidermal growth factor/α-transforming growth factor in human parturition

Roberto Romero; Ying King Wu; Enrique Oyarzun; John C. Hobbins; Murray D. Mitchell

doi:10.1016/0028-2243(89)90078-6

A potential role for epidermal growth factor/α-transforming growth factor in human parturition

Roberto Romero^*, Ying King Wu, Enrique Oyarzun, John C. Hobbins, Murray D. Mitchell

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

Epidermal growth factor (EGF)/α-transforming growth factor (α-TGF) concentrations were measured in amniotic fluid by radioreceptor assay in non-laboring and laboring patients at term. The median concentrations of EGF/α-TGF were 1.28 ng/ml and 5.0 ng/ml in non-laboring and laboring patients respectively (p < 0.05, Wilcoxon test). EGF was then incubated with amnion cells in monolayer culture to ascertain the effect of this hormone on the release of prostaglandin E₂. Experiments were carried out in quadruplicate in 11 separate primary amnion-cell cultures (EGF was used at 1 ng/ml and 5 ng/ml, respectively). An increased release of prostaglandin E₂ into the media was found. The response was concentration-de-pendent (p < 0.01). We suggest that there may be a role for EGF in the mechanism of human parturition.

Original language	English
Pages (from-to)	55-60
Number of pages	6
Journal	European Journal of Obstetrics and Gynecology and Reproductive Biology
Volume	33
Issue number	1
DOIs	https://doi.org/10.1016/0028-2243(89)90078-6
State	Published - Oct 1989
Externally published	Yes

Bibliographical note

Funding Information:
We thank professorM .J.N.C. Kierse from the Leiden University, The Netherlands, for the kind gift of antibodya gainstP GE,, and Camille Grzyboski, C.M.T. for expertt echnicala ssistanceT.h is studyw as supportedb y Grants from the Walter Scott Foundationf or Medical Researcha nd NIH grantsH D 20747a nd HD 20779. R.R. is the recipient of a Physician Scientist Award grant from the National Instituteso f Health.

Keywords

Growth factor, epidermal
Growth factor, α-transforming
Human parturition

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/0028-2243(89)90078-6

Cite this

@article{e9116261f7fe4ba79245f521cc1d8dfe,

title = "A potential role for epidermal growth factor/α-transforming growth factor in human parturition",

abstract = "Epidermal growth factor (EGF)/α-transforming growth factor (α-TGF) concentrations were measured in amniotic fluid by radioreceptor assay in non-laboring and laboring patients at term. The median concentrations of EGF/α-TGF were 1.28 ng/ml and 5.0 ng/ml in non-laboring and laboring patients respectively (p < 0.05, Wilcoxon test). EGF was then incubated with amnion cells in monolayer culture to ascertain the effect of this hormone on the release of prostaglandin E2. Experiments were carried out in quadruplicate in 11 separate primary amnion-cell cultures (EGF was used at 1 ng/ml and 5 ng/ml, respectively). An increased release of prostaglandin E2 into the media was found. The response was concentration-de-pendent (p < 0.01). We suggest that there may be a role for EGF in the mechanism of human parturition.",

keywords = "Growth factor, epidermal, Growth factor, α-transforming, Human parturition",

author = "Roberto Romero and {King Wu}, Ying and Enrique Oyarzun and Hobbins, {John C.} and Mitchell, {Murray D.}",

note = "Funding Information: We thank professorM .J.N.C. Kierse from the Leiden University, The Netherlands, for the kind gift of antibodya gainstP GE,, and Camille Grzyboski, C.M.T. for expertt echnicala ssistanceT.h is studyw as supportedb y Grants from the Walter Scott Foundationf or Medical Researcha nd NIH grantsH D 20747a nd HD 20779. R.R. is the recipient of a Physician Scientist Award grant from the National Instituteso f Health.",

year = "1989",

month = oct,

doi = "10.1016/0028-2243(89)90078-6",

language = "English",

volume = "33",

pages = "55--60",

journal = "European Journal of Obstetrics and Gynecology and Reproductive Biology",

issn = "0028-2243",

publisher = "Elsevier Ireland Ltd",

number = "1",

}

TY - JOUR

T1 - A potential role for epidermal growth factor/α-transforming growth factor in human parturition

AU - Romero, Roberto

AU - King Wu, Ying

AU - Oyarzun, Enrique

AU - Hobbins, John C.

AU - Mitchell, Murray D.

N1 - Funding Information: We thank professorM .J.N.C. Kierse from the Leiden University, The Netherlands, for the kind gift of antibodya gainstP GE,, and Camille Grzyboski, C.M.T. for expertt echnicala ssistanceT.h is studyw as supportedb y Grants from the Walter Scott Foundationf or Medical Researcha nd NIH grantsH D 20747a nd HD 20779. R.R. is the recipient of a Physician Scientist Award grant from the National Instituteso f Health.

PY - 1989/10

Y1 - 1989/10

N2 - Epidermal growth factor (EGF)/α-transforming growth factor (α-TGF) concentrations were measured in amniotic fluid by radioreceptor assay in non-laboring and laboring patients at term. The median concentrations of EGF/α-TGF were 1.28 ng/ml and 5.0 ng/ml in non-laboring and laboring patients respectively (p < 0.05, Wilcoxon test). EGF was then incubated with amnion cells in monolayer culture to ascertain the effect of this hormone on the release of prostaglandin E2. Experiments were carried out in quadruplicate in 11 separate primary amnion-cell cultures (EGF was used at 1 ng/ml and 5 ng/ml, respectively). An increased release of prostaglandin E2 into the media was found. The response was concentration-de-pendent (p < 0.01). We suggest that there may be a role for EGF in the mechanism of human parturition.

AB - Epidermal growth factor (EGF)/α-transforming growth factor (α-TGF) concentrations were measured in amniotic fluid by radioreceptor assay in non-laboring and laboring patients at term. The median concentrations of EGF/α-TGF were 1.28 ng/ml and 5.0 ng/ml in non-laboring and laboring patients respectively (p < 0.05, Wilcoxon test). EGF was then incubated with amnion cells in monolayer culture to ascertain the effect of this hormone on the release of prostaglandin E2. Experiments were carried out in quadruplicate in 11 separate primary amnion-cell cultures (EGF was used at 1 ng/ml and 5 ng/ml, respectively). An increased release of prostaglandin E2 into the media was found. The response was concentration-de-pendent (p < 0.01). We suggest that there may be a role for EGF in the mechanism of human parturition.

KW - Growth factor, epidermal

KW - Growth factor, α-transforming

KW - Human parturition

UR - http://www.scopus.com/inward/record.url?scp=0024434422&partnerID=8YFLogxK

U2 - 10.1016/0028-2243(89)90078-6

DO - 10.1016/0028-2243(89)90078-6

M3 - Article

C2 - 2806707

AN - SCOPUS:0024434422

SN - 0028-2243

VL - 33

SP - 55

EP - 60

JO - European Journal of Obstetrics and Gynecology and Reproductive Biology

JF - European Journal of Obstetrics and Gynecology and Reproductive Biology

IS - 1

ER -

A potential role for epidermal growth factor/α-transforming growth factor in human parturition

Abstract

Bibliographical note

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this