A potential role for epidermal growth factor/α-transforming growth factor in human parturition

Roberto Romero, Ying King Wu, Enrique Oyarzun, John C. Hobbins, Murray D. Mitchell

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

Epidermal growth factor (EGF)/α-transforming growth factor (α-TGF) concentrations were measured in amniotic fluid by radioreceptor assay in non-laboring and laboring patients at term. The median concentrations of EGF/α-TGF were 1.28 ng/ml and 5.0 ng/ml in non-laboring and laboring patients respectively (p < 0.05, Wilcoxon test). EGF was then incubated with amnion cells in monolayer culture to ascertain the effect of this hormone on the release of prostaglandin E2. Experiments were carried out in quadruplicate in 11 separate primary amnion-cell cultures (EGF was used at 1 ng/ml and 5 ng/ml, respectively). An increased release of prostaglandin E2 into the media was found. The response was concentration-de-pendent (p < 0.01). We suggest that there may be a role for EGF in the mechanism of human parturition.
Original languageAmerican English
Pages (from-to)55-60
Number of pages6
JournalEuropean Journal of Obstetrics and Gynecology and Reproductive Biology
Volume33
Issue number1
DOIs
StatePublished - 1 Jan 1989
Externally publishedYes

Keywords

  • Growth factor, epidermal
  • Growth factor, α-transforming
  • Human parturition

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