A multinational study to pilot the modified Hypomania Checklist (mHCL) in the assessment of mixed depression

Kursat Altinbas; Aysegul Ozerdem; Miguel L. Prieto; Manuel E. Fuentes; Nefize Yalin; Zeliha Ersoy; Omer Aydemir; Danilo Quiroz; Signem Oztekin; Jennifer R. Geske; Scott E. Feeder; Jules Angst; Mark A. Frye

doi:10.1016/j.jad.2013.07.032

A multinational study to pilot the modified Hypomania Checklist (mHCL) in the assessment of mixed depression

Kursat Altinbas, Aysegul Ozerdem, Miguel L. Prieto, Manuel E. Fuentes, Nefize Yalin, Zeliha Ersoy, Omer Aydemir, Danilo Quiroz, Signem Oztekin, Jennifer R. Geske, Scott E. Feeder, Jules Angst, Mark A. Frye^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Background Mixed depression is a common, dimensional phenomenon that is increasingly recognized in unipolar and bipolar disorders. We piloted a modified version of the Hypomania Checklist (mHCL-32) to assess the prevalence and clinical correlates of concurrent manic (hypo) symptoms in depressed patients. Methods The mHCL-32, Young Mania Rating Scale (YMRS) and Hamilton Rating Scale for Depression (HAMD-24) were utilized in the assessment of unipolar (UP=61) and bipolar (BP=44) patients with an index major depressive episode confirmed by the Structured Clinical Interview for DSM-IV (SCID). Differential mHLC-32 item endorsement was compared between UP and BP. Correlation analyses assessed the association of symptom dimensions measured by mHCL-32, YMRS and HAMD-24. Results There was no significant difference between mood groups in the mean mHCL-32 and YMRS scores. Individual mHLC-32 items of increased libido, quarrels, and caffeine intake were endorsed more in BP vs. UP patients. The mHCL-32 active-elevated subscale score was positively correlated with the YMRS in BP patients and negatively correlated with HAMD-24 in UP patients. Conversely, the mHCL-32 irritable-risk taking subscale score was positively correlated with HAMD-24 in BP and with YMRS in UP patients. Limitations Small sample size and cross-sectional design. Conclusion Modifying the HCL to screen for (hypo) manic symptoms in major depression may have utility in identifying mixed symptoms in both bipolar vs. unipolar depression. Further research is encouraged to quantify mixed symptoms with standardized assessments.

Original language	English
Pages (from-to)	478-482
Number of pages	5
Journal	Journal of Affective Disorders
Volume	152-154
Issue number	1
DOIs	https://doi.org/10.1016/j.jad.2013.07.032
State	Published - Jan 2014

Bibliographical note

Funding Information:
Dr. Frye has been a consultant (unpaid) for Allergan, Merck, Myriad, Sanofi-Aventis, Sunovion, Takeda Global Research, Teva Pharmaceuticals, United Biosource Corporation, has received grant support from Myriad, Pfizer, National Alliance for Schizophrenia and Depression (NARSAD), National Institute of Mental Health (NIMH), National Institute of Alcohol Abuse and Alcoholism (NIAAA), Mayo Foundation and has received travel support from Chilean Society of Neurology, Psychiatry and Neurosurgery (Sociedad de Neurologia, Psiquiatria y Neurocirugia), Advanced Health Media, GlaxoSmithKline, Colombian Society of Neuropsychopharmacology, AstraZeneca, Bristol-Myers-Squib, Otsuka, Sanofi-Aventis.

Funding Information:
Dr. Ozerdem has received honoraria from Astra Zeneca, BMS, Egis, GSK, Nobel, Pfizer, Servier and travel grants from Lundbeck, Nobel, Abdi İbrahim.

Funding Information:
Dr. Prieto has received honoraria for speaker activities and development of educational presentations from GlaxoSmithKline, has received travel support from GlaxoSmithKline, Lilly, Lundbeck, Pharmavita, and has received scholarship support from the Government of Chile.

Keywords

Bipolar
Depression
Modified hypomania checklist
Unipolar

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jad.2013.07.032

Cite this

Altinbas, K., Ozerdem, A., Prieto, M. L., Fuentes, M. E., Yalin, N., Ersoy, Z., Aydemir, O., Quiroz, D., Oztekin, S., Geske, J. R., Feeder, S. E., Angst, J., & Frye, M. A. (2014). A multinational study to pilot the modified Hypomania Checklist (mHCL) in the assessment of mixed depression. Journal of Affective Disorders, 152-154(1), 478-482. https://doi.org/10.1016/j.jad.2013.07.032

@article{ab7784bcedec44348f929531de73d4f5,

title = "A multinational study to pilot the modified Hypomania Checklist (mHCL) in the assessment of mixed depression",

abstract = "Background Mixed depression is a common, dimensional phenomenon that is increasingly recognized in unipolar and bipolar disorders. We piloted a modified version of the Hypomania Checklist (mHCL-32) to assess the prevalence and clinical correlates of concurrent manic (hypo) symptoms in depressed patients. Methods The mHCL-32, Young Mania Rating Scale (YMRS) and Hamilton Rating Scale for Depression (HAMD-24) were utilized in the assessment of unipolar (UP=61) and bipolar (BP=44) patients with an index major depressive episode confirmed by the Structured Clinical Interview for DSM-IV (SCID). Differential mHLC-32 item endorsement was compared between UP and BP. Correlation analyses assessed the association of symptom dimensions measured by mHCL-32, YMRS and HAMD-24. Results There was no significant difference between mood groups in the mean mHCL-32 and YMRS scores. Individual mHLC-32 items of increased libido, quarrels, and caffeine intake were endorsed more in BP vs. UP patients. The mHCL-32 active-elevated subscale score was positively correlated with the YMRS in BP patients and negatively correlated with HAMD-24 in UP patients. Conversely, the mHCL-32 irritable-risk taking subscale score was positively correlated with HAMD-24 in BP and with YMRS in UP patients. Limitations Small sample size and cross-sectional design. Conclusion Modifying the HCL to screen for (hypo) manic symptoms in major depression may have utility in identifying mixed symptoms in both bipolar vs. unipolar depression. Further research is encouraged to quantify mixed symptoms with standardized assessments.",

keywords = "Bipolar, Depression, Modified hypomania checklist, Unipolar",

author = "Kursat Altinbas and Aysegul Ozerdem and Prieto, {Miguel L.} and Fuentes, {Manuel E.} and Nefize Yalin and Zeliha Ersoy and Omer Aydemir and Danilo Quiroz and Signem Oztekin and Geske, {Jennifer R.} and Feeder, {Scott E.} and Jules Angst and Frye, {Mark A.}",

note = "Funding Information: Dr. Frye has been a consultant (unpaid) for Allergan, Merck, Myriad, Sanofi-Aventis, Sunovion, Takeda Global Research, Teva Pharmaceuticals, United Biosource Corporation, has received grant support from Myriad, Pfizer, National Alliance for Schizophrenia and Depression (NARSAD), National Institute of Mental Health (NIMH), National Institute of Alcohol Abuse and Alcoholism (NIAAA), Mayo Foundation and has received travel support from Chilean Society of Neurology, Psychiatry and Neurosurgery (Sociedad de Neurologia, Psiquiatria y Neurocirugia), Advanced Health Media, GlaxoSmithKline, Colombian Society of Neuropsychopharmacology, AstraZeneca, Bristol-Myers-Squib, Otsuka, Sanofi-Aventis. Funding Information: Dr. Ozerdem has received honoraria from Astra Zeneca, BMS, Egis, GSK, Nobel, Pfizer, Servier and travel grants from Lundbeck, Nobel, Abdi İbrahim. Funding Information: Dr. Prieto has received honoraria for speaker activities and development of educational presentations from GlaxoSmithKline, has received travel support from GlaxoSmithKline, Lilly, Lundbeck, Pharmavita, and has received scholarship support from the Government of Chile. ",

year = "2014",

month = jan,

doi = "10.1016/j.jad.2013.07.032",

language = "English",

volume = "152-154",

pages = "478--482",

journal = "Journal of Affective Disorders",

issn = "0165-0327",

publisher = "Elsevier",

number = "1",

}

Altinbas, K, Ozerdem, A, Prieto, ML, Fuentes, ME, Yalin, N, Ersoy, Z, Aydemir, O, Quiroz, D, Oztekin, S, Geske, JR, Feeder, SE, Angst, J & Frye, MA 2014, 'A multinational study to pilot the modified Hypomania Checklist (mHCL) in the assessment of mixed depression', Journal of Affective Disorders, vol. 152-154, no. 1, pp. 478-482. https://doi.org/10.1016/j.jad.2013.07.032

TY - JOUR

T1 - A multinational study to pilot the modified Hypomania Checklist (mHCL) in the assessment of mixed depression

AU - Altinbas, Kursat

AU - Ozerdem, Aysegul

AU - Prieto, Miguel L.

AU - Fuentes, Manuel E.

AU - Yalin, Nefize

AU - Ersoy, Zeliha

AU - Aydemir, Omer

AU - Quiroz, Danilo

AU - Oztekin, Signem

AU - Geske, Jennifer R.

AU - Feeder, Scott E.

AU - Angst, Jules

AU - Frye, Mark A.

N1 - Funding Information: Dr. Frye has been a consultant (unpaid) for Allergan, Merck, Myriad, Sanofi-Aventis, Sunovion, Takeda Global Research, Teva Pharmaceuticals, United Biosource Corporation, has received grant support from Myriad, Pfizer, National Alliance for Schizophrenia and Depression (NARSAD), National Institute of Mental Health (NIMH), National Institute of Alcohol Abuse and Alcoholism (NIAAA), Mayo Foundation and has received travel support from Chilean Society of Neurology, Psychiatry and Neurosurgery (Sociedad de Neurologia, Psiquiatria y Neurocirugia), Advanced Health Media, GlaxoSmithKline, Colombian Society of Neuropsychopharmacology, AstraZeneca, Bristol-Myers-Squib, Otsuka, Sanofi-Aventis. Funding Information: Dr. Ozerdem has received honoraria from Astra Zeneca, BMS, Egis, GSK, Nobel, Pfizer, Servier and travel grants from Lundbeck, Nobel, Abdi İbrahim. Funding Information: Dr. Prieto has received honoraria for speaker activities and development of educational presentations from GlaxoSmithKline, has received travel support from GlaxoSmithKline, Lilly, Lundbeck, Pharmavita, and has received scholarship support from the Government of Chile.

PY - 2014/1

Y1 - 2014/1

N2 - Background Mixed depression is a common, dimensional phenomenon that is increasingly recognized in unipolar and bipolar disorders. We piloted a modified version of the Hypomania Checklist (mHCL-32) to assess the prevalence and clinical correlates of concurrent manic (hypo) symptoms in depressed patients. Methods The mHCL-32, Young Mania Rating Scale (YMRS) and Hamilton Rating Scale for Depression (HAMD-24) were utilized in the assessment of unipolar (UP=61) and bipolar (BP=44) patients with an index major depressive episode confirmed by the Structured Clinical Interview for DSM-IV (SCID). Differential mHLC-32 item endorsement was compared between UP and BP. Correlation analyses assessed the association of symptom dimensions measured by mHCL-32, YMRS and HAMD-24. Results There was no significant difference between mood groups in the mean mHCL-32 and YMRS scores. Individual mHLC-32 items of increased libido, quarrels, and caffeine intake were endorsed more in BP vs. UP patients. The mHCL-32 active-elevated subscale score was positively correlated with the YMRS in BP patients and negatively correlated with HAMD-24 in UP patients. Conversely, the mHCL-32 irritable-risk taking subscale score was positively correlated with HAMD-24 in BP and with YMRS in UP patients. Limitations Small sample size and cross-sectional design. Conclusion Modifying the HCL to screen for (hypo) manic symptoms in major depression may have utility in identifying mixed symptoms in both bipolar vs. unipolar depression. Further research is encouraged to quantify mixed symptoms with standardized assessments.

AB - Background Mixed depression is a common, dimensional phenomenon that is increasingly recognized in unipolar and bipolar disorders. We piloted a modified version of the Hypomania Checklist (mHCL-32) to assess the prevalence and clinical correlates of concurrent manic (hypo) symptoms in depressed patients. Methods The mHCL-32, Young Mania Rating Scale (YMRS) and Hamilton Rating Scale for Depression (HAMD-24) were utilized in the assessment of unipolar (UP=61) and bipolar (BP=44) patients with an index major depressive episode confirmed by the Structured Clinical Interview for DSM-IV (SCID). Differential mHLC-32 item endorsement was compared between UP and BP. Correlation analyses assessed the association of symptom dimensions measured by mHCL-32, YMRS and HAMD-24. Results There was no significant difference between mood groups in the mean mHCL-32 and YMRS scores. Individual mHLC-32 items of increased libido, quarrels, and caffeine intake were endorsed more in BP vs. UP patients. The mHCL-32 active-elevated subscale score was positively correlated with the YMRS in BP patients and negatively correlated with HAMD-24 in UP patients. Conversely, the mHCL-32 irritable-risk taking subscale score was positively correlated with HAMD-24 in BP and with YMRS in UP patients. Limitations Small sample size and cross-sectional design. Conclusion Modifying the HCL to screen for (hypo) manic symptoms in major depression may have utility in identifying mixed symptoms in both bipolar vs. unipolar depression. Further research is encouraged to quantify mixed symptoms with standardized assessments.

KW - Bipolar

KW - Depression

KW - Modified hypomania checklist

KW - Unipolar

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U2 - 10.1016/j.jad.2013.07.032

DO - 10.1016/j.jad.2013.07.032

M3 - Article

C2 - 24070907

AN - SCOPUS:84889100550

SN - 0165-0327

VL - 152-154

SP - 478

EP - 482

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

IS - 1

ER -

A multinational study to pilot the modified Hypomania Checklist (mHCL) in the assessment of mixed depression

Abstract

Bibliographical note

Keywords

UN SDGs

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