48-month clinical evaluation of a copper-containing universal adhesive in non-carious cervical lesions: A double-blind randomised clinical trial

Thalita P. Matos, Romina Ñaupari-Villasante, Patrícia Valeria Manozzo Kunz, Viviane Hass, Alessandra Reis, Mario F. Gutiérrez*, Alessandro D. Loguercio

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: This study aimed to evaluate the effect of copper nanoparticles (CuNp) on the clinical performance of a universal adhesive system used as an etch-and-rinse or self-etch strategy. Methods: A total of 216 class V (non-carious lesions) restorations were randomly placed in 36 subjects according to the following groups: ERcu, adhesive in etch-and-rinse with 0.1% CuNp; ERct, adhesive in etch-and-rinse without CuNp; SEcu, adhesive in self-etch with 0.1% CuNp; and Sect, adhesive in self-etch without CuNp. Restorations were evaluated at baseline and at 6, 12, 18, 36, and 48 months, using the FDI and USPHS criteria. Appropriate statistical analyses were performed (α = 0.05). Results: After 48 months, 14 restorations were lost (two for ERcu, five for SEcu, and seven for SEct) and the retention rates (95% confidence interval [CI]) were 74.1% for ERcu (95% CI 61.1–83.8); 81.5% for ERct (95% CI 69.2–89.6); 64.8% (95% CI 51.5–76.2) for SEcu; and 64.8% (95% CI 51.5–76.2) for SEct, with statistical differences between SEct vs. ERct and SEcu vs. ERct (p < 0.05). No significant differences between the groups were observed when the secondary parameters were evaluated (p > 0.05). Nineteen restorations (two for ERcu, two for ERct, six for SEcu, and nine for SEct) showed minor marginal staining, and 44 restorations (7 for ERcu, 8 for ERct, 14 for SEcu, and 15 for SEct) presented minimal marginal adaptation defects. Significance: This is the first long-term clinical trial to show that the addition of CuNp to a universal adhesive system does not affect clinical performance.

Original languageEnglish
Pages (from-to)820-830
Number of pages11
JournalDental Materials
Volume39
Issue number9
DOIs
StatePublished - Sep 2023

Bibliographical note

Funding Information:
This study was partially supported by the National Council for Scientific and Technological Development (CNPq) under grants 304817/2021–0 and 308286/2019–7 , Coordenaç ão de Aperfeiçoamento de Pessoal de N í vel Superior - Brasil ( CAPES ) - Finance Code 001 , and by Agencia Nacional de Investigación y Desarrollo ( ANID ) and Fondo Nacional de Desarrollo Científico y Tecnológico ( Fondecyt ) under Fondecyt Initiation Grant 11221070 , Chile.

Publisher Copyright:
© 2023 Elsevier Inc.

Keywords

  • Clinical trial
  • Copper nanoparticles
  • Longevity
  • Non-carious cervical lesion
  • Universal adhesive system

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