18-month clinical evaluation of a copper-containing universal adhesive in non-carious cervical lesions: A double-blind, randomized controlled trial

Thalita P. Matos; Mario F. Gutiérrez; Taise A. Hanzen; Pâmela Malaquias; Alexandra M. de Paula; Jullian J. de Souza; Viviane Hass; Eduardo Fernández; Alessandra Reis; Alessandro D. Loguercio

doi:10.1016/j.jdent.2019.103219

18-month clinical evaluation of a copper-containing universal adhesive in non-carious cervical lesions: A double-blind, randomized controlled trial

Thalita P. Matos, Mario F. Gutiérrez, Taise A. Hanzen, Pâmela Malaquias, Alexandra M. de Paula, Jullian J. de Souza, Viviane Hass, Eduardo Fernández, Alessandra Reis, Alessandro D. Loguercio^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Objective: This study aimed to evaluate the addition of copper nanoparticles (CuNp) on the clinical performance of a universal adhesive system used as etch-and-rinse (ER) and self-etch (SE). Methods: 216 restorations were randomly placed in 36 subjects according to the following groups: ERcu = etch-and-rinse with 0.1% CuNp; ERct = etch-and-rinse without CuNp; SEcu = self-etch with 0.1% CuNp; SEct = self-etch without CuNp. Resin composite was placed incrementally and light-cured. The restorations were evaluated at baseline and 6, 12 and 18 months using the FDI and USPHS criteria. Statistical analyses were performed using appropriate tests (α = 0.05). Results: The addition of CuNp did not increase the clinical performance (FDI / USPHS) of the universal adhesive tested after 18-month when applied in the ER mode (p > 0.05). The addition of CuNp in SE restorations increased the retention rate significantly and decreased the marginal discrepancies after 18 months (p < 0.05). Conclusion: The clinical performance of universal adhesive was significantly increased when applied in the SE mode with the addition of copper nanoparticles. Clinical relevance: This is the first study that demonstrates a slight improvement in the clinical performance of universal adhesive systems in non-carious cervical lesions when added CuNp in lower concentration.

Original language	English
Article number	103219
Journal	Journal of Dentistry
Volume	90
DOIs	https://doi.org/10.1016/j.jdent.2019.103219
State	Published - Nov 2019
Externally published	Yes

Bibliographical note

Funding Information:
This study was performed by Thalita de Paris Matos as partial fulfillment of his MSc degree at the State University of Ponta Grossa (UEPG), Ponta Grossa, PR, Brazil. This study was partially supported by the National Council for Scientific and Technological Development (CNPq) under grants 305588/2014-1 , 303332/2017-4 and in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) - Finance Code 001 and by the Fondecyt under grant 1170575 – Chile.

Publisher Copyright:
© 2019 Elsevier Ltd

Keywords

Clinical trial
Copper nanoparticles
Longevity
Non-carious cervical lesion
Universal adhesive system

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10.1016/j.jdent.2019.103219

Cite this

Matos, T. P., Gutiérrez, M. F., Hanzen, T. A., Malaquias, P., de Paula, A. M., de Souza, J. J., Hass, V., Fernández, E., Reis, A., & Loguercio, A. D. (2019). 18-month clinical evaluation of a copper-containing universal adhesive in non-carious cervical lesions: A double-blind, randomized controlled trial. Journal of Dentistry, 90, [103219]. https://doi.org/10.1016/j.jdent.2019.103219

@article{03573a15a39843eea7b45e153267b562,

title = "18-month clinical evaluation of a copper-containing universal adhesive in non-carious cervical lesions: A double-blind, randomized controlled trial",

abstract = "Objective: This study aimed to evaluate the addition of copper nanoparticles (CuNp) on the clinical performance of a universal adhesive system used as etch-and-rinse (ER) and self-etch (SE). Methods: 216 restorations were randomly placed in 36 subjects according to the following groups: ERcu = etch-and-rinse with 0.1% CuNp; ERct = etch-and-rinse without CuNp; SEcu = self-etch with 0.1% CuNp; SEct = self-etch without CuNp. Resin composite was placed incrementally and light-cured. The restorations were evaluated at baseline and 6, 12 and 18 months using the FDI and USPHS criteria. Statistical analyses were performed using appropriate tests (α = 0.05). Results: The addition of CuNp did not increase the clinical performance (FDI / USPHS) of the universal adhesive tested after 18-month when applied in the ER mode (p > 0.05). The addition of CuNp in SE restorations increased the retention rate significantly and decreased the marginal discrepancies after 18 months (p < 0.05). Conclusion: The clinical performance of universal adhesive was significantly increased when applied in the SE mode with the addition of copper nanoparticles. Clinical relevance: This is the first study that demonstrates a slight improvement in the clinical performance of universal adhesive systems in non-carious cervical lesions when added CuNp in lower concentration.",

keywords = "Clinical trial, Copper nanoparticles, Longevity, Non-carious cervical lesion, Universal adhesive system",

author = "Matos, {Thalita P.} and Guti{\'e}rrez, {Mario F.} and Hanzen, {Taise A.} and P{\^a}mela Malaquias and {de Paula}, {Alexandra M.} and {de Souza}, {Jullian J.} and Viviane Hass and Eduardo Fern{\'a}ndez and Alessandra Reis and Loguercio, {Alessandro D.}",

note = "Funding Information: This study was performed by Thalita de Paris Matos as partial fulfillment of his MSc degree at the State University of Ponta Grossa (UEPG), Ponta Grossa, PR, Brazil. This study was partially supported by the National Council for Scientific and Technological Development (CNPq) under grants 305588/2014-1 , 303332/2017-4 and in part by the Coordena{\c c}{\~a}o de Aperfei{\c c}oamento de Pessoal de N{\'i}vel Superior - Brasil (CAPES) - Finance Code 001 and by the Fondecyt under grant 1170575 – Chile. Publisher Copyright: {\textcopyright} 2019 Elsevier Ltd",

year = "2019",

month = nov,

doi = "10.1016/j.jdent.2019.103219",

language = "English",

volume = "90",

journal = "Journal of Dentistry",

issn = "0300-5712",

publisher = "Elsevier BV",

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TY - JOUR

T1 - 18-month clinical evaluation of a copper-containing universal adhesive in non-carious cervical lesions

T2 - A double-blind, randomized controlled trial

AU - Matos, Thalita P.

AU - Gutiérrez, Mario F.

AU - Hanzen, Taise A.

AU - Malaquias, Pâmela

AU - de Paula, Alexandra M.

AU - de Souza, Jullian J.

AU - Hass, Viviane

AU - Fernández, Eduardo

AU - Reis, Alessandra

AU - Loguercio, Alessandro D.

N1 - Funding Information: This study was performed by Thalita de Paris Matos as partial fulfillment of his MSc degree at the State University of Ponta Grossa (UEPG), Ponta Grossa, PR, Brazil. This study was partially supported by the National Council for Scientific and Technological Development (CNPq) under grants 305588/2014-1 , 303332/2017-4 and in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) - Finance Code 001 and by the Fondecyt under grant 1170575 – Chile. Publisher Copyright: © 2019 Elsevier Ltd

PY - 2019/11

Y1 - 2019/11

N2 - Objective: This study aimed to evaluate the addition of copper nanoparticles (CuNp) on the clinical performance of a universal adhesive system used as etch-and-rinse (ER) and self-etch (SE). Methods: 216 restorations were randomly placed in 36 subjects according to the following groups: ERcu = etch-and-rinse with 0.1% CuNp; ERct = etch-and-rinse without CuNp; SEcu = self-etch with 0.1% CuNp; SEct = self-etch without CuNp. Resin composite was placed incrementally and light-cured. The restorations were evaluated at baseline and 6, 12 and 18 months using the FDI and USPHS criteria. Statistical analyses were performed using appropriate tests (α = 0.05). Results: The addition of CuNp did not increase the clinical performance (FDI / USPHS) of the universal adhesive tested after 18-month when applied in the ER mode (p > 0.05). The addition of CuNp in SE restorations increased the retention rate significantly and decreased the marginal discrepancies after 18 months (p < 0.05). Conclusion: The clinical performance of universal adhesive was significantly increased when applied in the SE mode with the addition of copper nanoparticles. Clinical relevance: This is the first study that demonstrates a slight improvement in the clinical performance of universal adhesive systems in non-carious cervical lesions when added CuNp in lower concentration.

AB - Objective: This study aimed to evaluate the addition of copper nanoparticles (CuNp) on the clinical performance of a universal adhesive system used as etch-and-rinse (ER) and self-etch (SE). Methods: 216 restorations were randomly placed in 36 subjects according to the following groups: ERcu = etch-and-rinse with 0.1% CuNp; ERct = etch-and-rinse without CuNp; SEcu = self-etch with 0.1% CuNp; SEct = self-etch without CuNp. Resin composite was placed incrementally and light-cured. The restorations were evaluated at baseline and 6, 12 and 18 months using the FDI and USPHS criteria. Statistical analyses were performed using appropriate tests (α = 0.05). Results: The addition of CuNp did not increase the clinical performance (FDI / USPHS) of the universal adhesive tested after 18-month when applied in the ER mode (p > 0.05). The addition of CuNp in SE restorations increased the retention rate significantly and decreased the marginal discrepancies after 18 months (p < 0.05). Conclusion: The clinical performance of universal adhesive was significantly increased when applied in the SE mode with the addition of copper nanoparticles. Clinical relevance: This is the first study that demonstrates a slight improvement in the clinical performance of universal adhesive systems in non-carious cervical lesions when added CuNp in lower concentration.

KW - Clinical trial

KW - Copper nanoparticles

KW - Longevity

KW - Non-carious cervical lesion

KW - Universal adhesive system

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U2 - 10.1016/j.jdent.2019.103219

DO - 10.1016/j.jdent.2019.103219

M3 - Article

C2 - 31629030

AN - SCOPUS:85074427025

SN - 0300-5712

VL - 90

JO - Journal of Dentistry

JF - Journal of Dentistry

M1 - 103219

ER -

18-month clinical evaluation of a copper-containing universal adhesive in non-carious cervical lesions: A double-blind, randomized controlled trial

Abstract

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Keywords

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