ω-3 long-chain polyunsaturated fatty acids and fatty acid desaturase activity ratios as eventual endophenotypes for ADHD

Marcela Henríquez-Henríquez; Sandra Solari; Gisela Várgas; Luis Vásquez; Fidel Allende; S. Carla Castañón; Marcela Tenorio; Teresa Quiroga Gutiérrez

doi:10.1177/1087054712461175

ω-3 long-chain polyunsaturated fatty acids and fatty acid desaturase activity ratios as eventual endophenotypes for ADHD

Marcela Henríquez-Henríquez^*, Sandra Solari, Gisela Várgas, Luis Vásquez, Fidel Allende, S. Carla Castañón, Marcela Tenorio, Teresa Quiroga Gutiérrez

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Objective: Epidemiological studies suggest that long-chain polyunsaturated fatty acids (LC-PUFAs) may be suitable as endophenotypes for ADHD. To be appropriated vulnerability traits, endophenotypes should be altered in unaffected relatives of index cases. Serum profiles of LC-PUFAs in unaffected relatives of ADHD patients remain understudied. The main objective of this study was to compare serum LC-PUFAs in ADHD patients, unaffected relatives of index cases, and general-population unaffected participants. Method: LC-PUFA profiles of 72 participants (27 ADHD patients, 27 unaffected relatives, and 18 general-population participants) were obtained by gas chromatography-mass spectrometry (GC-MS). Groups were compared by parametrical statistics. Results: Unaffected females from the general population presented lower Docosapentaenoic acid (DPA; p =.0012) and a-linolenic acid (ALA; p =.0091) levels compared with ADHD females and unaffected relatives. In addition, docosahexaenoic acid (DHA)/ALA and DHA/DPA ratios, addressing desaturase activity, were significantly lower in ADHD patients and unaffected relatives of ADHD patients in the female-subgroup (p =.022 and.04, respectively). Conclusion: DHA/ALA, DHA/DPA, serum DPA, and serum ALA may be suitable as endophenotypes for ADHD women.

Original language	English
Pages (from-to)	977-986
Number of pages	10
Journal	Journal of Attention Disorders
Volume	19
Issue number	11
DOIs	https://doi.org/10.1177/1087054712461175
State	Published - Nov 2015
Externally published	Yes

Bibliographical note

Funding Information:
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by funds from School of Medicine, Pontificia Universidad Católica de Chile.

Publisher Copyright:
© The Author(s) 2012.

Keywords

ADHD
Endophenotype
LC-PUFAs
W-3

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10.1177/1087054712461175

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@article{44b6f98ee02f4d7fb9c2b00f6fba9815,

title = "ω-3 long-chain polyunsaturated fatty acids and fatty acid desaturase activity ratios as eventual endophenotypes for ADHD",

abstract = "Objective: Epidemiological studies suggest that long-chain polyunsaturated fatty acids (LC-PUFAs) may be suitable as endophenotypes for ADHD. To be appropriated vulnerability traits, endophenotypes should be altered in unaffected relatives of index cases. Serum profiles of LC-PUFAs in unaffected relatives of ADHD patients remain understudied. The main objective of this study was to compare serum LC-PUFAs in ADHD patients, unaffected relatives of index cases, and general-population unaffected participants. Method: LC-PUFA profiles of 72 participants (27 ADHD patients, 27 unaffected relatives, and 18 general-population participants) were obtained by gas chromatography-mass spectrometry (GC-MS). Groups were compared by parametrical statistics. Results: Unaffected females from the general population presented lower Docosapentaenoic acid (DPA; p =.0012) and a-linolenic acid (ALA; p =.0091) levels compared with ADHD females and unaffected relatives. In addition, docosahexaenoic acid (DHA)/ALA and DHA/DPA ratios, addressing desaturase activity, were significantly lower in ADHD patients and unaffected relatives of ADHD patients in the female-subgroup (p =.022 and.04, respectively). Conclusion: DHA/ALA, DHA/DPA, serum DPA, and serum ALA may be suitable as endophenotypes for ADHD women.",

keywords = "ADHD, Endophenotype, LC-PUFAs, W-3",

author = "Marcela Henr{\'i}quez-Henr{\'i}quez and Sandra Solari and Gisela V{\'a}rgas and Luis V{\'a}squez and Fidel Allende and {Carla Casta{\~n}{\'o}n}, S. and Marcela Tenorio and Guti{\'e}rrez, {Teresa Quiroga}",

note = "Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by funds from School of Medicine, Pontificia Universidad Cat{\'o}lica de Chile. Publisher Copyright: {\textcopyright} The Author(s) 2012.",

year = "2015",

month = nov,

doi = "10.1177/1087054712461175",

language = "English",

volume = "19",

pages = "977--986",

journal = "Journal of Attention Disorders",

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TY - JOUR

T1 - ω-3 long-chain polyunsaturated fatty acids and fatty acid desaturase activity ratios as eventual endophenotypes for ADHD

AU - Henríquez-Henríquez, Marcela

AU - Solari, Sandra

AU - Várgas, Gisela

AU - Vásquez, Luis

AU - Allende, Fidel

AU - Carla Castañón, S.

AU - Tenorio, Marcela

AU - Gutiérrez, Teresa Quiroga

N1 - Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by funds from School of Medicine, Pontificia Universidad Católica de Chile. Publisher Copyright: © The Author(s) 2012.

PY - 2015/11

Y1 - 2015/11

N2 - Objective: Epidemiological studies suggest that long-chain polyunsaturated fatty acids (LC-PUFAs) may be suitable as endophenotypes for ADHD. To be appropriated vulnerability traits, endophenotypes should be altered in unaffected relatives of index cases. Serum profiles of LC-PUFAs in unaffected relatives of ADHD patients remain understudied. The main objective of this study was to compare serum LC-PUFAs in ADHD patients, unaffected relatives of index cases, and general-population unaffected participants. Method: LC-PUFA profiles of 72 participants (27 ADHD patients, 27 unaffected relatives, and 18 general-population participants) were obtained by gas chromatography-mass spectrometry (GC-MS). Groups were compared by parametrical statistics. Results: Unaffected females from the general population presented lower Docosapentaenoic acid (DPA; p =.0012) and a-linolenic acid (ALA; p =.0091) levels compared with ADHD females and unaffected relatives. In addition, docosahexaenoic acid (DHA)/ALA and DHA/DPA ratios, addressing desaturase activity, were significantly lower in ADHD patients and unaffected relatives of ADHD patients in the female-subgroup (p =.022 and.04, respectively). Conclusion: DHA/ALA, DHA/DPA, serum DPA, and serum ALA may be suitable as endophenotypes for ADHD women.

AB - Objective: Epidemiological studies suggest that long-chain polyunsaturated fatty acids (LC-PUFAs) may be suitable as endophenotypes for ADHD. To be appropriated vulnerability traits, endophenotypes should be altered in unaffected relatives of index cases. Serum profiles of LC-PUFAs in unaffected relatives of ADHD patients remain understudied. The main objective of this study was to compare serum LC-PUFAs in ADHD patients, unaffected relatives of index cases, and general-population unaffected participants. Method: LC-PUFA profiles of 72 participants (27 ADHD patients, 27 unaffected relatives, and 18 general-population participants) were obtained by gas chromatography-mass spectrometry (GC-MS). Groups were compared by parametrical statistics. Results: Unaffected females from the general population presented lower Docosapentaenoic acid (DPA; p =.0012) and a-linolenic acid (ALA; p =.0091) levels compared with ADHD females and unaffected relatives. In addition, docosahexaenoic acid (DHA)/ALA and DHA/DPA ratios, addressing desaturase activity, were significantly lower in ADHD patients and unaffected relatives of ADHD patients in the female-subgroup (p =.022 and.04, respectively). Conclusion: DHA/ALA, DHA/DPA, serum DPA, and serum ALA may be suitable as endophenotypes for ADHD women.

KW - ADHD

KW - Endophenotype

KW - LC-PUFAs

KW - W-3

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U2 - 10.1177/1087054712461175

DO - 10.1177/1087054712461175

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C2 - 23100268

AN - SCOPUS:84943526504

SN - 1087-0547

VL - 19

SP - 977

EP - 986

JO - Journal of Attention Disorders

JF - Journal of Attention Disorders

IS - 11

ER -

ω-3 long-chain polyunsaturated fatty acids and fatty acid desaturase activity ratios as eventual endophenotypes for ADHD

Abstract

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Keywords

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