κ-B like DNA-binding activity is enhanced after spaced training that induces long-term memory in the crab Chasmagnathus

Ramiro Freudenthal; Fernando Locatelli; Gabriela Hermitte; Héctor Maldonado; Carlos Lafourcade; Alejandro Delorenzi; Arturo Romano

doi:10.1016/S0304-3940(98)00059-7

κ-B like DNA-binding activity is enhanced after spaced training that induces long-term memory in the crab Chasmagnathus

Ramiro Freudenthal, Fernando Locatelli, Gabriela Hermitte, Héctor Maldonado, Carlos Lafourcade, Alejandro Delorenzi, Arturo Romano^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

83 Scopus citations

Abstract

Regulation of gene expression has been involved in long-term memory consolidation. Present results support the role of Rel/NFκ-B like activation in this process. In the crab Chasmagnathus, the spaced presentation of 15 or more danger stimuli induces long-term habituation (LTH), while no LTH is observed after a massed training of 600 trials. When a group trained with 30 spaced trials was compared with a passive control group and massed trained groups, a higher level of specific Rel/κ-B like DNA-binding activity was found in brain nuclear extracts. These results strongly suggest that the enhancement of Rel/κ-B like DNA-binding activity in the brain is specifically related to LTH formation.

Original language	English
Pages (from-to)	143-146
Number of pages	4
Journal	Neuroscience Letters
Volume	242
Issue number	3
DOIs	https://doi.org/10.1016/S0304-3940(98)00059-7
State	Published - 20 Feb 1998
Externally published	Yes

Bibliographical note

Funding Information:
We would especially like to thank Alberto Kornblitth for his support and helpful discussion and comments on the manuscript. We would also like to thank Angel Vidal for technical assistance. This work was supported by CONICET-Argentina and University of Buenos Aires grants.

Keywords

Crab
Dorsal/Dif
Gel shift
Habituation
Long-term memory
Rel/NFκ-B
Transcription factors

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10.1016/S0304-3940(98)00059-7

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title = "κ-B like DNA-binding activity is enhanced after spaced training that induces long-term memory in the crab Chasmagnathus",

abstract = "Regulation of gene expression has been involved in long-term memory consolidation. Present results support the role of Rel/NFκ-B like activation in this process. In the crab Chasmagnathus, the spaced presentation of 15 or more danger stimuli induces long-term habituation (LTH), while no LTH is observed after a massed training of 600 trials. When a group trained with 30 spaced trials was compared with a passive control group and massed trained groups, a higher level of specific Rel/κ-B like DNA-binding activity was found in brain nuclear extracts. These results strongly suggest that the enhancement of Rel/κ-B like DNA-binding activity in the brain is specifically related to LTH formation.",

keywords = "Crab, Dorsal/Dif, Gel shift, Habituation, Long-term memory, Rel/NFκ-B, Transcription factors",

author = "Ramiro Freudenthal and Fernando Locatelli and Gabriela Hermitte and H{\'e}ctor Maldonado and Carlos Lafourcade and Alejandro Delorenzi and Arturo Romano",

note = "Funding Information: We would especially like to thank Alberto Kornblitth for his support and helpful discussion and comments on the manuscript. We would also like to thank Angel Vidal for technical assistance. This work was supported by CONICET-Argentina and University of Buenos Aires grants.",

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T1 - κ-B like DNA-binding activity is enhanced after spaced training that induces long-term memory in the crab Chasmagnathus

AU - Freudenthal, Ramiro

AU - Locatelli, Fernando

AU - Hermitte, Gabriela

AU - Maldonado, Héctor

AU - Lafourcade, Carlos

AU - Delorenzi, Alejandro

AU - Romano, Arturo

N1 - Funding Information: We would especially like to thank Alberto Kornblitth for his support and helpful discussion and comments on the manuscript. We would also like to thank Angel Vidal for technical assistance. This work was supported by CONICET-Argentina and University of Buenos Aires grants.

PY - 1998/2/20

Y1 - 1998/2/20

N2 - Regulation of gene expression has been involved in long-term memory consolidation. Present results support the role of Rel/NFκ-B like activation in this process. In the crab Chasmagnathus, the spaced presentation of 15 or more danger stimuli induces long-term habituation (LTH), while no LTH is observed after a massed training of 600 trials. When a group trained with 30 spaced trials was compared with a passive control group and massed trained groups, a higher level of specific Rel/κ-B like DNA-binding activity was found in brain nuclear extracts. These results strongly suggest that the enhancement of Rel/κ-B like DNA-binding activity in the brain is specifically related to LTH formation.

AB - Regulation of gene expression has been involved in long-term memory consolidation. Present results support the role of Rel/NFκ-B like activation in this process. In the crab Chasmagnathus, the spaced presentation of 15 or more danger stimuli induces long-term habituation (LTH), while no LTH is observed after a massed training of 600 trials. When a group trained with 30 spaced trials was compared with a passive control group and massed trained groups, a higher level of specific Rel/κ-B like DNA-binding activity was found in brain nuclear extracts. These results strongly suggest that the enhancement of Rel/κ-B like DNA-binding activity in the brain is specifically related to LTH formation.

KW - Crab

KW - Dorsal/Dif

KW - Gel shift

KW - Habituation

KW - Long-term memory

KW - Rel/NFκ-B

KW - Transcription factors

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DO - 10.1016/S0304-3940(98)00059-7

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AN - SCOPUS:0032548758

SN - 0304-3940

VL - 242

SP - 143

EP - 146

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 3

ER -

κ-B like DNA-binding activity is enhanced after spaced training that induces long-term memory in the crab Chasmagnathus

Abstract

Bibliographical note

Keywords

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