κ-B like DNA-binding activity is enhanced after spaced training that induces long-term memory in the crab Chasmagnathus

Ramiro Freudenthal, Fernando Locatelli, Gabriela Hermitte, Héctor Maldonado, Carlos Lafourcade, Alejandro Delorenzi, Arturo Romano*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

81 Scopus citations

Abstract

Regulation of gene expression has been involved in long-term memory consolidation. Present results support the role of Rel/NFκ-B like activation in this process. In the crab Chasmagnathus, the spaced presentation of 15 or more danger stimuli induces long-term habituation (LTH), while no LTH is observed after a massed training of 600 trials. When a group trained with 30 spaced trials was compared with a passive control group and massed trained groups, a higher level of specific Rel/κ-B like DNA-binding activity was found in brain nuclear extracts. These results strongly suggest that the enhancement of Rel/κ-B like DNA-binding activity in the brain is specifically related to LTH formation.

Original languageEnglish
Pages (from-to)143-146
Number of pages4
JournalNeuroscience Letters
Volume242
Issue number3
DOIs
StatePublished - 20 Feb 1998
Externally publishedYes

Bibliographical note

Funding Information:
We would especially like to thank Alberto Kornblitth for his support and helpful discussion and comments on the manuscript. We would also like to thank Angel Vidal for technical assistance. This work was supported by CONICET-Argentina and University of Buenos Aires grants.

Keywords

  • Crab
  • Dorsal/Dif
  • Gel shift
  • Habituation
  • Long-term memory
  • Rel/NFκ-B
  • Transcription factors

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